Find NHLBI Clinical Trials

Search selected NHLBI-supported clinical trials and observational studies by condition, location, or age group. You can also view the complete list of NHLBI-funded studies at ClinicalTrials.gov.

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Showing 1 - 10 out of 12 results
Recruiting
Do you or your child have severe sickle cell disease and also know a half-matched bone marrow donor? This study is seeking to improve bone marrow transplantation success from half-matched donors by testing a different conditioning procedure that uses a variety of medicines to prepare for the transplant. To participate in this study, you must be 15 to 45 years old and have severe sickle cell disease or have a child 5 to 14 years old who has had a stroke. This study is located in many sites across the United States, including Miami, Florida, and St. Louis, Missouri.
Child, Adult
Recruiting
Are you scheduled for a stem cell transplant with cord blood? This study will assess the safety and effectiveness of certain cord blood transplants. The study will help researchers learn the best methods for collecting, storing, and using cord blood in transplants. To participate in this study, you must have a disorder that compromises your body’s ability to make blood cells. This study is located in Bethesda, Maryland.
All Ages
Recruiting
California
Tennessee
Washington
Do you know a newborn or toddler who has severe combined immunodeficiency? This study will test the safety and effectiveness of genetic therapies to treat X-linked severe combined immunodeficiency (SCID-X1), a rare genetic immune disorder. The therapies could be a new approach to treat SCID-X1 in people who do not have a brother or sister to be a donor for stem cell transplant. To participate in this study, the child must be 2 years old or younger. This study is located in Memphis, Tennessee; San Francisco, California; and Seattle, Washington.
Child
Male
Recruiting
Are you an adult woman who would like to help develop methods to prevent the worsening of LAM? This study aims to discover whether earlier and longer treatment with a lower dose of sirolimus can help prevent LAM from getting worse over time. To participate in this study, you must be female, be at least 18 years old, and have been diagnosed with LAM. This study is located in Atlanta, Georgia; Boston, Massachusetts; Chicago, Illinois; Cincinnati, Ohio; Denver, Colorado; Nashville, Tennessee; Palo Alto, California; Philadelphia, Pennsylvania; and Seattle, Washington.
Adult, Older Adult
Female
Recruiting
Do you or your child have dilated cardiomyopathy? This study aims to investigate the genetic causes of dilated cardiomyopathy to improve early diagnosis and prevention. To participate in this study, you or your child can be any age but must have dilated cardiomyopathy. This study takes place at multiple locations across the United States.
All Ages
Recruiting
Washington
Are you an adult with pulmonary arterial hypertension (PAH) and currently taking vasodilators? This study is testing the efficacy of a new medicine called famotidine for people with PAH. Participants in this study must be between 18 and 80 years old and willing to take famotidine or a placebo for 6 months. This study takes place in Seattle, Washington.
Adult, Older Adult
Recruiting
Do you or your child have severe sickle cell disease? This study tests the rate of event-free survival 2 years after receiving a haploidentical bone marrow transplantation. A haploidentical transplant is also called a half-matched transplant. Participants of this study will also have to take certain medicines, including thymoglobulin, cyclophosphamide, fludarabine, and thiotepa. To participate in this study, you or your child must be between 5 and 45 years old. This study takes place in multiple locations across the United States.
Child, Adult
Recruiting
Washington
Are you an adult diagnosed with cystic fibrosis who would like to help test web-based educational resources designed to inform and prepare patients to make decisions about lung transplantation? This study will determine if it is feasible for study participants to complete use of an assigned web-based educational program, and evaluate whether providing certain educational resources leaves participants more prepared to make future treatment decisions involving lung transplantation with their health care provider(s). To participate in this study, you must be at least 18 years old. This study takes place in Seattle, Washington.
Adult, Older Adult
Recruiting
Are you an adult who has been diagnosed with idiopathic pulmonary fibrosis (IPF)? This study will examine whether adding N-acetylcysteine (NAC) to standard treatment improves key indicators of IPF, including symptoms, in people with the TOLLIP rs3750920 TT genotype who are living with the disease. You must be age 40 or older to participate in this study. This study takes place in multiple locations.
Adult, Older Adult