Clinical Trials and Studies

his trial will evaluate an oral drug discovered in a high throughput screen, which increases fetal globin protein (HbF and red blood cells expressing HbF)and messenger ribonucleic acid (mRNA) to high levels in anemic nonhuman primates and in transgenic mice.

Sickle Cell Disease (SCD) impairs oxygen transport to tissue and causes endothelial injury. Thus, therapeutic interventions aim to improve both, but there is an unmet need for biomarkers to determine when intervention is necessary and evaluate the effectiveness of the chosen intervention in individual patients. This study proposes to monitor SCD and its treatment through their impact on cerebral hemodynamics, as the brain is one of the most vulnerable and consequential targets of the disease. Specifically, this study will optimize quantitative magnetic resonance imaging (MRI) and advanced optical spectroscopy techniques such as frequency-domain near-infrared and diffuse correlation spectroscopies (FDNIRS-DCS) to monitor 1) cerebral oxygen transport with measures of cerebral blood flow (CBF), cerebral oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen consumption (CMRO2) and 2) endothelial function with cerebrovascular reactivity (CVR).

Are you an adult with primary light chain amyloidosis? Researchers in this study are investigating new ways to look at the heart to identify when it is not working properly. You may be able to participate if you are at least 18 years old and have been diagnosed with primary light chain amyloidosis. This study is taking place in Boston, Massachusetts.

The objective of the ALA-LHC is to establish a national cohort of young adults for the purpose of defining lung health and developing targets to intercept chronic lung disease at its earliest stages.

Are you a woman between 18 and 35 years old? This trial is studying how healthy women who have not gone through menopause react to sleep loss at different times during their menstrual cycle. Participants will be exposed to different sleep patterns during the study. The study is taking place in Boston, Massachusetts.

Do you do shift work and are interested in metabolic health? This study looks at how diet may affect circadian misalignment. To join, you must be 18 to 45 years old and in good health. As a participant, you will stay in the study hospital twice and get all your meals during the study. The study is taking place at Brigham and Women's Hospital in Boston, Massachusetts.

Do you have chronic kidney disease? If you are at least 21 years old, you may be able to participate in this study of a medication typically used to treat gout to see if can be used to treat people with chronic kidney disease. The study is taking place in Boston, Massachusetts.

Are you interested in your platelet function? Researchers are evaluating a new platelet function test. This study will help scientists improve the accuracy of the new test in healthy individuals and individuals with obesity. To participate in this study, you should be 18 years old or older and be healthy or have obesity. This study is recruiting in Boston, Massachusetts.

Were you diagnosed with heart failure within the past 6 months? In this clinical trial, researchers are studying whether a medication given through an IV can improve exercise capacity for patients with heart failure. Participants will have other tests and blood work to see how the heart and lungs react to the medication. You must be at least 18 years old to participate. The study is taking place in Boston, Massachusetts.

Are you 75 years old or older and interested in participating in a clinical trial where researchers are studying whether statins, which are often used to treat high cholesterol, can help improve heart and brain health. To participate, you cannot have cardiovascular disease or dementia. The study is taking place at locations in Alabama, Arizona, Arkansas, California, Connecticut, Florida, Georgia, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Nebraska, Nevada, New York, North Carolina, Ohio, Pennsylvania, Rhode Island, South Carolina, Tennessee, Texas, Utah, Virginia, West Virginia, Wisconsin, and Puerto Rico.