Clinical Trials

This study is testing whether a new imaging technique can help healthcare providers diagnose venous thromboembolism. To participate in this study, you must be at least 18 years old and diagnosed with venous thromboembolism. This study takes place in Boston, Massachusetts.

Are you an adult with severe asthma who plans to have bronchial thermoplasty treatment? This study is using a new imaging technique, called optical coherence tomography, to examine the airways in people with asthma before and after a treatment called bronchial thermoplasty. This treatment is minimally invasive and reduces asthma symptoms by using heat to shrink smooth muscle within the lungs. To participate in this survey, you must be between 18 and 60 years old. This study takes place in Boston, Massachusetts.

Do you or your child have severe asthma that is not easily controlled by inhaled corticosteroids? This study evaluates the use of five different asthma medicines to treat adults and adolescents with severe asthma. To participate in this study, you or your child must be 12 years old or older. This study takes place in multiple locations across the United States.

Are you a woman 18 years old or older who has been diagnosed with LAM? This study is examining whether long-term treatment with medicine called sirolimus can stop lung damage in women who have LAM. This study takes place at multiple locations in the United States.

Are you an adult with obstructive sleep apnea? This study is examining how using continuous positive airway pressure (CPAP) to treat sleep apnea affects a person’s blood oxygen levels, heart rate, and quality of sleep. To participate in this study, you must be between 20 and 80 years old with moderate to severe obstructive sleep apnea. This study takes place in Boston, Massachusetts.

Are you a transportation shift worker? This study is testing new methods to raise awareness about obstructive sleep apnea in this group. The study will test whether personalized messages can help encourage participants to get tested for sleep apnea and to stick to their treatment plans. This study takes place in Boston, Massachusetts.

The Bashir™ Endovascular Catheter has been designed to administer therapeutic agents in the peripheral vasculature. Because of the unique design of the catheter, with its six expandable infusion limbs, the Bashir™ Endovascular Catheter has the ability to: 1. Create a much larger central channel for blood flow, thereby utilizing the body's own endogenous fibrinolytic agents to lyse the clot, and 2. Greatly enhance the radial dispersion of a catheter-administered thrombolytic agent throughout the thrombus. Expansion of the multiple arms of the basket in the infusion catheter causes fissuring of the clot. The net result is that a greater surface area of clot is exposed to both endogenous and exogenously administered lytic agents, thereby promoting clot dissolution.

Are you an adult who has had Fontan palliation operation? If so, you may be able to join a clinical trial where researchers learn more about how the heart and lungs work after a Fontan palliation. Researchers will perform a procedure called a cardiac catheterization while participants exercise to see how well the heart is working. Participants must be at least 18 years old. The study is taking place in Rochester, Minnesota.

Women who experience hot flashes are at greater risk for hypertension and other cardiovascular disease. In this clinical trial, researchers are studying the link between hot flashes and cardiovascular disease in women. Participants must be between 40 and 60 years old and must not have cardiovascular disease. The study is taking place in Rochester, Minnesota.

Have you had a heart attack caused by spontaneous coronary artery dissection (SCAD)? Most patients with SCAD do not have traditional risk factors such as tobacco use, high cholesterol, diabetes, but rather, they the heart attack is caused by other problems with the heart. In this clinical trial, researchers are studying people who have had SCAD to understand what may cause this to happen. The study is taking place in Rochester, Minnesota.