Clinical Trials

Do you or your child have severe asthma that is not easily controlled by inhaled corticosteroids? This study evaluates the use of five different asthma medicines to treat adults and adolescents with severe asthma. To participate in this study, you or your child must be 12 years old or older. This study takes place in multiple locations across the United States.

Do you or your child have primary ciliary dyskinesia (PCD) or primary immune deficiency (PID)? This study aims to identify genes that cause these two conditions, which can have similar symptoms. The results from this study will help researchers find new ways to treat breathing and hearing problems caused by these two conditions in a cross-sectional cohort of patients with PCD and PID. Participants in this study must be 5 to 45 years old. This study is taking place at multiple locations in the United States and in Canada.

Do you or your child have symptoms of a serious lung disease but no diagnosis? This study aims to develop new ways to diagnose primary ciliary dyskinesia (PCD) and primary immune deficiency (PID), two conditions that can have similar symptoms. Researchers will combine information from genetic testing, lung imaging, and lung function tests to diagnose ant tell the difference between these two conditions. Participants in this study must be 5 to 45 years old. This study is taking place at multiple locations in the United States and in Canada.

The purpose of this study is to determine the occurrence of scarring of the heart (cardiac fibrosis) and inflammation in those with perinatally acquired Human Immunodeficiency Virus (HIV) infection compared to people not infected with HIV. The information learned from this research may help the investigator to better understand the link between cardiac fibrosis and cardiac dysfunction and inflammation in those with perinatally acquired HIV infection compared to the uninfected.

Are you an adult who gets little exercise and sits a lot every day? If you sit for more than 8 hours a day and exercise less than 90 minutes per week, this study may interest you. Researchers want to see if walking or standing breaks during long sitting periods can make your heart healthier. To take part in this study, you must be 36 to 55 years old. You also should be able to walk four blocks and go up two flights of stairs. The study is taking place in Chapel Hill, North Carolina.

The purpose of this research is to learn about how salt in the diet influences blood pressure in young adults who were born prematurely.

The objective of the ALA-LHC is to establish a national cohort of young adults for the purpose of defining lung health and developing targets to intercept chronic lung disease at its earliest stages.

The goal of this work is to develop and test a noninvasive ultrasound-based imaging technology to better identify patients at high risk of stroke so that appropriate and timely intervention may be administered to prevent it.

Do you have overweight or obesity? Researchers are testing whether messages sent through a mobile app can help people lose weight. To participate, you must be 18 to 39 years and own a smartphone with a data and text messaging plan. The study is taking place in Chapel Hill, North Carolina.

Are you an adult with heart failure? A clinical trial is testing if a supplement drink helps people with heart failure. Participants will visit the study site once where they will be served a light breakfast with the study’s supplement drink. Researchers will perform a physical exam and draw blood several times during the visit. The study is taking place in Durham, North Carolina.