Clinical Trials

Is your family from India, Pakistan, Bangladesh, Nepal, or Sri Lanka? If so, you may be able to participate in a clinical study looking at cardiovascular disease, such as heart disease and stroke among people of South Asian descent. Participants must be between 40 and 84 years old and have no history of heart attack or stroke, heart failure, angina, or atrial fibrillation. This study is taking place in San Francisco, California, Chicago, Illinois, and New York City, New York.

The main goal of this study is to determine whether the treatment will lead to a complete absence of severe vaso-occlusive events (VOEs) in patients with severe SCD.

Do you have both type II diabetes and obesity? Researchers are studying how exercise and weight-loss affect body fat tissues and cells in the body. Participants must be 18 to 50 years old and be able to do moderately intense physical activity. The study is taking place in Chicago, Illinois.

Are you 75 years old or older and interested in participating in a clinical trial where researchers are studying whether statins, which are often used to treat high cholesterol, can help improve heart and brain health. To participate, you cannot have cardiovascular disease or dementia. The study is taking place at locations in Alabama, Arizona, Arkansas, California, Connecticut, Florida, Georgia, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Nebraska, Nevada, New York, North Carolina, Ohio, Pennsylvania, Rhode Island, South Carolina, Tennessee, Texas, Utah, Virginia, West Virginia, Wisconsin, and Puerto Rico.

Do you have chronic kidney disease and mild heart failure? Researchers are testing a medication to see if it helps heart and lung function when it is added to your current medication. To take part in this clinical trial, you must be 18 to 85 years old, have chronic kidney disease and are taking diuretics or other medication, and have mild heart failure. The study is taking place in Chicago, Illinois.

The purpose of this study is to develop and optimize a targeted behavioral intervention for sleep disturbance among individuals who have recently lost a spouse/long-term cohabitating partner.

Do you or your child have sickle cell disease and also have an interest in contributing to long-term data collection? This study is monitoring patients and collecting biological samples from patients who have sickle cell disease to better understand long-term outcomes. Participants can be any age and must have sickle cell disease. This study is located in six sites in Illinois, Louisiana, North Carolina, and Tennessee.

Are you an adult with a diagnosed sleep phase disorder? This study aims to assess the sleep patterns and quality of sleep in people who have sleep phase disorders to determine how the disorders affect their circadian rhythms. To participate in this study, you must be at least 18 years old and have a sleep phase disorder, such as advanced sleep-wake phase syndrome or delayed sleep-wake phase syndrome. This study is located in Chicago, Illinois.

Are you between 40 and 85 with worsening idiopathic pulmonary fibrosis? This study aims to test a new combination treatment for acute exacerbations, a life-threatening complication of idiopathic pulmonary fibrosis (IPF) that has no approved treatment. The treatment is meant to help stop part of the immune system from further injuring the lung tissue. To participate in this study, you must be between 40 and 85 years old and have worsening IPF. This study is located in Birmingham, Alabama; Boston, Massachusetts; Philadelphia, Pennsylvania; and Pittsburgh, Pennsylvania.

Are you an adult interested in comparing effects of different exercise training on blood pressure? This study aims to compare how different types of exercise can affect blood pressure in African Americans. Participants will do either aerobic activities, focusing on raising their heart rate, or muscle-strengthening resistance activities, focusing on weights, for 24 to 26 weeks. To participate in this study, you must be between 18 and 50 years old, have a sedentary lifestyle and elevated blood pressure, and have been born in the United States to either two African American or two non-Hispanic Caucasian parents. This study is located in Chicago, Illinois.