Clinical Trials

Do you have bronchiectasis and get frequent lung infections? This study is exploring what causes frequent lung infections in people with bronchiectasis. Researchers will look at whether changes to a person's genes or immune system can raise the risk of these frequent infections. Participants in this study must be at least 5 years old and either healthy, diagnosed with bronchiectasis, or have a history of frequent lung infections. This study is located at the NIH Clinical Center in Bethesda, Maryland.

Are you an adult with MBL, CLL/SLL, LPL, WM, or SMZL? This study will follow people with these conditions before and after treatment to look at how their conditions progress or improve, with the goal of discovering new treatments. To participate in this study, you must be at least 18 years old. This study is located at the NIH Clinical Center in Bethesda, Maryland.

Are you a healthy adult or someone with a history of lung infections such as pneumonia or bronchitis? This study aims to compare fluid and tissue samples from the nose and lungs of healthy adults with people who have a lung disease. Researchers hope to learn why some people are more susceptible to certain infections. This study is located at the NIH Clinical Center in Bethesda, Maryland.

Are you or your child willing to donate blood or bone marrow to help research? This study collects samples of blood, bone marrow, and buccal mucosa (cells from the inside of the cheek). Researchers will use these samples to study blood cells, blood diseases, and the role of the immune system in conditions such as aplastic anemia. Participants in this study must be at least 8 years old. This study is located at the NIH Clinical Center in Bethesda, Maryland.

Do you or a child in your family have a cancerous tumor or blood disease? This study will collect blood, urine, or other samples to examine for potential new or improved treatments or prevention methods. Participants in this study must be 2 years or older and either have a cancerous tumor or a cancerous or non-cancerous blood disorder, or be a compatible family member for a stem cell transplant for the patient. This study is located at the NIH Clinical Center in Bethesda, Maryland.

Do you or your child have an immunodeficiency, such as fewer T cells or NK cells? You can help researchers better understand how some types of immunodeficiencies are inherited. Participants in this study must be at least 6 months of age. This study is located at the NIH Clinical Center in Bethesda, Maryland.

Do you have tuberous sclerosis and want to help researchers better understand the disease? This study is investigating what causes multiple skin tumors to develop in people with tuberous sclerosis. To participate in the study, you must be at least 18 years old. This study is located at the NIH Clinical Center in Bethesda, Maryland.

Are a healthy adult who is interested in helping people who need a bone marrow transplant? This procedure is often associated with life-threatening reactions, such as graft-versus-host disease (GHVD). This study will test a technique that uses peripheral blood instead of bone marrow. With this technique, they can transplant donor stem cells and remove lymphocytes, which are the white blood cells from donor bone marrow that can cause GHVD. To participate, you must be between 18 and 60 years old. This study is located at the NIH Clinical Center in Bethesda, Maryland.

Do you get less than 7 hours of sleep each day and take medicine for opioid use disorder (OUD)? This study is looking at how the brain systems that control sleep can affect medication-assisted treatment in people who have opioid use disorder. The study will test whether suvorexant can help improve sleep and reduce stress without interfering with treatments for OUD. To participate in this study, you must be 21 to 65 years old. This study takes place at various locations in Baltimore, Bel Air, and Elkton, Maryland.

Are you 65 years old or older, and do you have severe primary mitral regurgitation? This condition — also called degenerative mitral regurgitation — happens when there is a problem with the mitral valve itself or its supporting tissue, leading to a leaky valve. This study is comparing the safety and effectiveness of two different ways of repairing the mitral valve: transcatheter edge-to-edge repair and surgical repair. To participate in this study, your healthcare provider must determine that you are a candidate for both mitral valve transcatheter edge-to-edge repair and surgical repair. This study takes place in multiple locations across the United States and Canada.