Clinical Trials

Do you or a loved one have pneumonia? This study will test whether combining two medicines to reduce inflammation of the airway and to keep it open may help prevent respiratory failure in people who have pneumonia. To participate in this study, you must be at least 18 years old and have severe pneumonia with low blood oxygen levels.

Are you being treated in the ICU for acute respiratory failure? This study is looking at whether treating depression along with physical therapy helps people recover faster from respiratory failure. After leaving the ICU, you will be visited at your home by a physical therapist and occupational therapist who will talk to you about your goals for recovery and what activities you value the most. They will then design a plan for you that includes a type of talk therapy for depression called behavioral activation. To participate in this study, you must be at least 18 years old and undergoing treatment for acute respiratory failure for more than 24 hours in the ICU. This study is located in Baltimore, Maryland.

Do you get less than 7 hours of sleep each day and take medicine for opioid use disorder (OUD)? This study is looking at how the brain systems that control sleep can affect medication-assisted treatment in people who have opioid use disorder. The study will test whether suvorexant can help improve sleep and reduce stress without interfering with treatments for OUD. To participate in this study, you must be 21 to 65 years old. This study takes place at various locations in Baltimore, Bel Air, and Elkton, Maryland.