Clinical Trials

Have you lived in Alabama, Kentucky, Louisiana, or Mississippi for at least two years and are you interested in participating in a clinical study where researchers are trying to better understand health and disease in rural areas? The study team will track your physical activity using a provided Fitbit device and will also ask questions about your health and lifestyle through a cell phone app. You will also receive a kit to measure environmental and health factors in your homes. Participants must live in one of these counties: Dallas County, Alabama; Wilcox County, Alabama; Boyle County, Kentucky; Perry County, Kentucky; Garrard County, Kentucky; Breathitt County, Kentucky; Assumption Parish, Louisiana; Franklin Parish, Louisiana; Oktibbeha County, Mississippi; and Panola County, Mississippi.

The investigators' central hypothesis is that early combination therapy with two PAH-specific oral therapies that have been shown to be well tolerated in the pediatric population, sildenafil and bosentan, will result in better World Health Organization (WHO) functional class at 12 months after initiation of PAH treatment than therapy with sildenafil alone.

Do you or your child have pulmonary hypertension and want to help research? This study is looking to better understand pulmonary hypertension in children who have this condition. To participate in this study, you or your child must be 21 years old or younger and must have been diagnosed with pulmonary hypertension before the age of 18. This study is located at multiple sites across the United States and Canada, including California, Colorado, Massachusetts, New York, Pennsylvania, Tennessee, and Alberta, Canada.

Is your newborn in the neonatal intensive care unit at St. Louis Children’s Hospital? This study aims to better understand breathing problems and blood flow through the heart in premature newborns to better detect conditions such as pulmonary hypertension. To participate in this study, your newborn must have been born prematurely between 24 and 29 weeks’ gestation and be a patient in the Neonatal Intensive Care Unit at St. Louis Children’s Hospital. This study is located in St. Louis, Missouri.