Clinical Trials and Studies

Do you have a heart or blood vessel disease, such as peripheral artery disease? This study aims to collect data and samples from people who have a heart or blood vessel disease. This may include blood tests, ultrasound exams, and heart and lung tests. Family members and healthy people may also participate. The results may help researchers better understand PAD and other heart and blood vessel diseases. Participants must be at least 2 years old. Women who are pregnant may not take part in some study activities. This study is located in Bethesda, Maryland.

Do you or a first-degree relative have a condition that raises the risk of heart disease? This study aims to test the heart and lung function of people who have a genetic or metabolic disease that raises their risk of heart disease. Participants in this study must be between 2 and 100 years old. This study is located in Bethesda, Maryland.

Are you an adult who has PAD and difficulty walking? This study is testing whether a medicine that helps the body make more white blood cells can, along with walking exercise, improve symptoms and blood flow in people who have PAD. To participate in this study, you must be between 21 and 80 years old and have PAD. Women must not be pregnant and must use birth control or have been surgically sterilized if they still have menstrual periods. This study is located in Atlanta, Georgia.

Are you an adult who has PAD and overweight or obesity? This study aims to learn whether participating in an exercise program with a weight loss program reduces PAD signs and symptoms more than an exercise program alone. To participate, you must be between 18 and 85 years old, have PAD, and have a body mass index (BMI) greater than 28 but less than 45. Participants must also be willing to use a smartphone and attend weekly study sessions. This study is located in Evanston, Illinois; New Orleans, Louisiana; and Minneapolis, Minnesota.

Does your child have sleep apnea? To study sleep apnea, researchers use a sleep endoscopy to look at the airway in a sleeping patient. Researchers want to know how two types of anesthesia work during a sleep endoscopy. Your child may be able to join if they are between 3 and 11 years old and need to have their tonsils/adenoids removed. The trial is taking place in Ann Arbor, Michigan.

Have you recently learned you have sleep apnea? If so, you may be able to join this study. Researchers want to see if a medication can help lower the risk of cardiovascular disease in people with sleep apnea. You must be 18 years old. The study is taking place in New York City, New York.

Does your child have sleep apnea? Researchers are testing whether a device to help improve airflow in the upper airway can help people with sleep apnea. Participants must be between 3 and 21 years old and have obstructive sleep apnea. The study is taking place in Ann Arbor, Michigan.

Do you have sleep apnea? Sleep apnea creates difficulty breathing during sleep and affects millions of Americans. People with sleep apnea often are treated with continuous positive airway pressure to help them breathe at night but it may be uncomfortable for some. Researchers are testing whether a medication can help people with sleep apnea. Participants must be 18 years old and have sleep apnea that they are not treating. The study is taking place in La Jolla, California.

Has your child been referred to the Children's Hospital of Philadelphia to test for sleep apnea? Researchers are comparing different ways to test children for sleep apnea. Your child must be 5 to 12 years old to join. The study is taking place at the Children’s Hospital of Philadelphia.

Does your child have Down syndrome and sleep apnea? Researchers are trying to learn if medication can help with sleep apnea for children with Down syndrome. Your child may be able to join this study if they are 6 to 17 years old. The study is taking place in Tucson, Arizona.