Find NHLBI Clinical Trials

Search selected NHLBI-supported clinical trials and observational studies by condition, location, or age group. You can also view the complete list of NHLBI-funded studies at ClinicalTrials.gov.

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Showing 1 - 8 out of 8 results
Recruiting
Virginia
Health organizations recommend exercise in an intensity based manner to promote cardiovascular adaptation and prevent disease. Metformin is a common anti-diabetes medication that reduces future type 2 diabetes and cardiovascular disease (CVD) risk. However, the optimal dose of exercise to be combined with metformin for vascular health remains unknown. The purpose of this study is to evaluate whether combining high or low intensity exercise with metformin has the potential to outperform either exercise intensity alone on blood flow across the arterial tree as well as impact insulin action in individuals with metabolic syndrome.
Adult, Older Adult
Recruiting
Virginia
Do you have metabolic syndrome? This trial is testing whether low-intensity exercise or high-intensity exercise works best to lower the risk of heart and blood vessel diseases in people who have metabolic syndrome and are taking a medicine called metformin to treat high blood sugar levels. To participate in this study, you must be between 40 and 80 years old and diagnosed with metabolic syndrome but not type 2 diabetes. This study takes place in New Brunswick, New Jersey.
Adult, Older Adult
Recruiting
South Carolina
Do you or your child have overweight or obesity? This study aims to find effective ways to prevent and treat obesity and metabolic syndrome in African American communities. The study will test the effectiveness of a family-based comprehensive health and fitness programs involving community health workers. Participants must be 12 years old or older and African American and have overweight or obesity. This study takes place in Charleston, South Carolina.
All Ages
Recruiting
Texas
Does your child have higher triglyceride levels but normal cholesterol levels? This study is testing whether a protein supplement called carnitine can help prevent blood vessel stiffness in teenagers who have metabolic syndrome or other risk factors for heart and blood vessel diseases. Participants in this study must be between 13 and 19 years old and have moderate to high blood triglyceride levels but normal blood cholesterol levels. This study takes place in Houston, Texas.
Child, Adult
Recruiting
Massachusetts
Pulmonary rehabilitation (PR) is a structured program of exercise and self-management support that has been proven to relieve shortness of breath and increase quality of life when initiated after an exacerbation, but unfortunately, few eligible patients participate. This project will compare the effectiveness of two novel strategies - one involving video narratives of other patients telling their story of how they overcame challenges and completed PR, the other involving telephonic peer coaching with an individual with lived experience - to enhanced usual care, and to each other, at increasing patient participation in PR after an exacerbation.
Adult, Older Adult
Recruiting
New York
Are you an adult who has received urgent care for moderate to serious COPD in the past 4 weeks? This study aims to find out whether a method called Comprehensive Health Informatics Engagement Framework for Pulmonary Rehabilitation can help people who have COPD stick to their treatment plan. To participate in this study, you must be at least 18 years old. This study takes place in New York, New York.
Adult, Older Adult
Recruiting
Massachusetts
This study is testing whether a new imaging technique can help healthcare providers diagnose venous thromboembolism. To participate in this study, you must be at least 18 years old and diagnosed with venous thromboembolism. This study takes place in Boston, Massachusetts.
Adult, Older Adult
Recruiting
Pennsylvania
Are you a healthy adult between 40 and 90 years old and willing to help research? This study will test whether a new device called the OsciPulse system, which is designed to repeatedly compress a person’s legs, can improve blood flow through the legs to prevent or treat varicose veins. To participate in this study, you must be 40 to 90 years old and healthy. This study takes place in Philadelphia, Pennsylvania.
Adult, Older Adult
Accepting Healthy Volunteers