Clinical Trials

Would you like more support with your heart and metabolic health? Would you like more support with your heart and metabolic health? This study will provide patients with personalized information about community-based resources to support health-related social needs and heart and metabolic health. You may be able to participate if you are 2 years or older, African American or Black, and you have at least one cardiometabolic condition. Conditions may include being overweight, having high blood pressure, pre-diabetes or diabetes, and/or high cholesterol. This study is recruiting in Rocky Mount, North Carolina.

Do you or your child have dyslipidemia? This study is exploring how different diagnostic tests can help us understand how lipid disorders, including high blood cholesterol and high blood triglycerides, affect the body. Information from this study may help improve the way lipid disorders are diagnosed or treated in the future. Participants in this study must be at least 2 years old. The study is being conducted in Bethesda, Maryland.

Are you an adult who is healthy or has problems with the level of cholesterol or other lipids in the blood? This study is gathering information on the risk factors for very high or very low levels of lipids, or fats, in the blood. Researchers will collect participants’ demographic information, medical history, and blood samples. To participate in this study, you must be at least 18 years old. This study takes place in Dallas, Texas.

Do you suffer from insomnia? Do you suffer from insomnia? The kind of insomnia you have might have an impact on other health outcomes like blood pressure. This study will examine whether patients with short and normal sleep duration respond differently to two common insomnia treatments, Cognitive Behavioral Therapy for Insomnia or the medication trazodone. You may be able to participate if you are 18 years old or older and meet the criteria for chronic insomnia.

Are you currently enrolled in the Risk Underlying Rural Areas Longitudinal (RURAL) study and between the ages of 25 and 65? Are you currently enrolled in the Risk Underlying Rural Areas Longitudinal (RURAL) study and between the ages of 25 and 65? If so, you may be able to participate in a sub-study to help understand how sleep habits can contribute to heart health. This sub-study measures sleep apnea, sleep duration, timing, and regularity combined with questionnaire responses to assess insomnia, sleep quality, sleep-related impairment, and fatigue.

Do you have HIV and insomnia? This study is looking at whether insomnia increases pain and inflammation in people who have HIV. To participate in this study, you must be 18 to 85 years old and either be healthy or diagnosed with HIV, with or without insomnia. This study is located in Birmingham, Alabama.

Have you previously been prescribed opioid medicines? This study will find out whether waking up frequently during the night can affect the way your brain processes certain medicines. To participate in this study, you must be 18 to 48 years old, have a normal sleep cycle, and have previously taken opioid medicines to treat pain. This study is located in Baltimore, Maryland.

Do you or a loved one have pneumonia? This study will test whether combining two medicines to reduce inflammation of the airway and to keep it open may help prevent respiratory failure in people who have pneumonia. To participate in this study, you must be at least 18 years old and have severe pneumonia with low blood oxygen levels.

Do you have symptoms of a lung disease (such as long-term wet cough, bronchiectasis, or recurrent pneumonia) with no genetic diagnosis? This study aims to develop new ways to diagnose primary ciliary dyskinesia (PCD) or primary immune deficiency (PID), two conditions that can have similar symptoms. Researchers will combine information from genetic testing, lung imaging, and lung function tests to diagnose and tell the difference between these two conditions. Participants in this study must be 5 to 45 years old and must have symptoms of a serious lung disease but no diagnosis. This study is taking place at multiple locations in the United States and in Canada, including the NIH Clinical Center in Bethesda, Maryland.

Are you a healthy adult or someone with a history of lung infections such as pneumonia or bronchitis? This study aims to compare fluid and tissue samples from the nose and lungs of healthy adults with people who have a lung disease. Researchers hope to learn why some people are more susceptible to certain infections. This study is located at the NIH Clinical Center in Bethesda, Maryland.