Clinical Trials

Are you an adult who does not have high blood pressure and is interested in research? This study will investigate how the brain regulates the body’s response to stress and how infection with HIV or pre-hypertension affects regulation. Your heart and brain activity will be measured while you are at rest, during a mentally stressful task, and while you feel angry. The study will also test whether a breathing exercise improves regulation. People with and without HIV and pre-hypertension will be included. To participate in this study, you must be between 21 and 65 years old and not have high blood pressure. This study is located in Miami, Florida.

Do you or your child have dyslipidemia? This study is exploring how different diagnostic tests can help us understand how lipid disorders, including high blood cholesterol and high blood triglycerides, affect the body. Information from this study may help improve the way lipid disorders are diagnosed or treated in the future. Participants must be at least 2 years old. This study is located in Bethesda, Maryland.

Do you have overweight? Circadian rhythm disorders can cause overweight and obesity. This study is examining how not getting enough sleep causes these complications. To participate in this study, you must be between the ages of 20 and 40 and have overweight but not obesity. This study is located in New York, New York.

Are you a healthy adult who regularly sleeps for 6.5 or fewer hours? This study is examining whether getting enough sleep can lower your risk of high blood pressure. To participate in this study, you must be between 18 and 65 years old, regularly sleep for 6.5 or fewer hours, and be able to adjust your sleep schedule for the study. This study is located in Rochester, Minnesota.

Are you an African American woman at risk for diabetes? This study is testing whether using mobile health technology, such as smartphone apps and activity monitors, can help increase physical activity in African American women who are at risk for diabetes. To participate in this study, you must be an African American woman between 25 and 75 years old, have evidence of insulin resistance, and live in Prince George’s County, Maryland, or Ward 5, 7, or 8 in Washington, D.C. This study is located in Bethesda, Maryland.

Do you have a heart or blood vessel disease, such as peripheral artery disease? This study aims to collect data and samples from people who have a heart or blood vessel disease. This may include blood tests, ultrasound exams, and heart and lung tests. Family members and healthy people may also participate. The results may help researchers better understand PAD and other heart and blood vessel diseases. Participants must be at least 2 years old. Women who are pregnant may not take part in some study activities. This study is located in Bethesda, Maryland.

Are you an adult interested in comparing effects of different exercise training on blood pressure? This study aims to compare how different types of exercise can affect blood pressure in African Americans. Participants will do either aerobic activities, focusing on raising their heart rate, or muscle-strengthening resistance activities, focusing on weights, for 24 to 26 weeks. To participate in this study, you must be between 18 and 50 years old, have a sedentary lifestyle and elevated blood pressure, and have been born in the United States to either two African American or two non-Hispanic Caucasian parents. This study is located in Chicago, Illinois.

Are you at least 21 years old, and do you have heart failure? This study aims to better understand why heart failure can make it hard to exercise and perform daily activities. This complication is called exercise intolerance. Participants in the study will complete physical activities and then undergo magnetic resonance imaging (MRI) to look for changes in the chemicals the body uses for energy. To participate in this study, you must be at least 21 years old, diagnosed with heart failure, and be medically stable. This study is located in Baltimore, Maryland.

Are you an adult who has uncontrolled high blood pressure? This study will see whether an early notification system for health professionals can help manage patients’ high blood pressure, especially among those who have had a stroke or have an increased risk of stroke. To participate in this study, you must be between 18 and 85 years old and have high blood pressure that is not controlled by medicine and lifestyle changes. This study is enrolling native English, Spanish, or Hmong speakers. The study is located in Minneapolis, Minnesota.

Do you take medicine for high blood pressure or high blood cholesterol? This study will test a program that asks pharmacists to reach out to patients who have high blood pressure, high blood cholesterol, or diabetes and help them stick to their plans for taking and refilling their medicines as prescribed. To participate in this study, you must be between 18 and 75 years old. The study location is in Bloomington, Minnesota.