Find NHLBI Clinical Trials and Studies

Search selected NHLBI-supported  clinical trials  and  observational studies  by condition, location, or age group. You can also view the complete list of NHLBI-funded studies at ClinicalTrials.gov.

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Showing 1 - 5 out of 5 results
Recruiting
Pennsylvania
The purpose of this study is to non-invasively characterize the fibrotic consequences of single ventricle physiology, its possible solution and effect on lymphatics. This project investigates the response to acute imposition of Fontan hemodynamics by examining the interrelationship between liver and cardiac fibrosis/dysfunction and lymphatic congestion along with a pilot trial of the antifibrotic agent, spironolactone, to prevent these consequences and to determine if MRI can discern these differences. The combination of serum biomarkers and MRI form a powerful non-invasive tool in putting together this complicated web of dysfunction.
Child
Recruiting
Alabama
The purpose of this study is to determine if acquired (partial) Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) deficiency contributes substantially to the pathogenic mechanisms underlying Chronic Rhinosinusitis (CRS), creating a localized environment that impairs mucociliary clearance (MCC).
Adult, Older Adult
Recruiting
Do you have cystic fibrosis and are you a parent? This study will determine how parenthood affects the health of people with cystic fibrosis. To participate in the study, you must have a diagnosis of cystic fibrosis and you must be a first-time biological or non-biological parent to a child under 5 years old. You cannot participate in the study if you have had a lung transplant. The study is in multiple locations.
Adult, Older Adult
Recruiting
Maryland
Do you or your child have a lung disease? This study will investigate the genes involved in the breathing process and in the development of lung diseases such as asthma or sarcoidosis to improve understanding of the role they play. To participate in this study, you or your child must be between 2 and 90 years old. This study is located in Bethesda, Maryland, at the NIH Clinical Center.
All Ages
Accepting Healthy Volunteers