Clinical Trials

Women who experience hot flashes are at greater risk for hypertension and other cardiovascular disease. In this clinical trial, researchers are studying the link between hot flashes and cardiovascular disease in women. Participants must be between 40 and 60 years old and must not have cardiovascular disease. The study is taking place in Rochester, Minnesota.

Are you 75 years old or older and interested in participating in a clinical trial where researchers are studying whether statins, which are often used to treat high cholesterol, can help improve heart and brain health. To participate, you cannot have cardiovascular disease or dementia. The study is taking place at locations in Alabama, Arizona, Arkansas, California, Connecticut, Florida, Georgia, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Nebraska, Nevada, New York, North Carolina, Ohio, Pennsylvania, Rhode Island, South Carolina, Tennessee, Texas, Utah, Virginia, West Virginia, Wisconsin, and Puerto Rico.

Have you had a heart attack caused by spontaneous coronary artery dissection (SCAD)? Most patients with SCAD do not have traditional risk factors such as tobacco use, high cholesterol, diabetes, but rather, they the heart attack is caused by other problems with the heart. In this clinical trial, researchers are studying people who have had SCAD to understand what may cause this to happen. The study is taking place in Rochester, Minnesota.

Do you have mitral valve disease? This clinical trial is testing different types of images taken of the heart to learn more about mitral valve disease and the best ways to treat it. You must be 60 years old to participate. The study is enrolling patients in locations in Arkansas, California, Georgia, Indiana, Louisiana, Maine, Maryland, Massachusetts, Michigan, Missouri, New York, North Carolina, Ohio, Pennsylvania, and Quebec City, Canada.

Are you an adult who has had Fontan palliation operation? If so, you may be able to join a clinical trial where researchers learn more about how the heart and lungs work after a Fontan palliation. Researchers will perform a procedure called a cardiac catheterization while participants exercise to see how well the heart is working. Participants must be at least 18 years old. The study is taking place in Rochester, Minnesota.

Are you an adult with mild heart failure and a left bundle branch block? This study will test whether a type of pacemaker called a cardiac resynchronization device can help the heart pump more blood in people who have mild heart failure (HF) and left bundle branch block. In the study, participants will have a cardiac resynchronization device implanted. This study is located in Bethesda, Maryland.

Do you want to help find new treatments for heart failure with preserved ejection fraction? This study is testing whether a medicine called spironolactone can help treat heart failure with preserved ejection fraction when paired with the standard treatment. Spironolactone helps to remove excess water and sodium from the body. To participate in this study, you must be between 50 and 99 years old and diagnosed with heart failure with preserved ejection fraction.

Are you an adult with mild heart failure (HF) and left bundle branch block (LBBB)? LBBB is a heart condition in which there is a delay or blockage of electrical signals to the left side of the heart. This study is exploring the use of a treatment called cardiac resynchronization therapy (CRT) in people with HF and LBBB. To have CRT, participants must be willing to have an implanted device, called a biventricular pacemaker, that helps the chambers of the heart work together to pump blood more efficiently. To participate in this study, you must be at least 18 years old. This study takes place in Rochester, Minnesota.

Do you have heart failure with preserved ejection fraction (HFPEF)? This study is testing the efficacy of a diuretic medicine called spironolactone that stops your body from absorbing too much salt and keeps your potassium levels from dropping too low. Participants of this study must be between 50 and 99 years old and already taking diuretic medicine. This study takes place in multiple locations across the United States and Sweden.