Clinical Trials and Studies

Are you between the ages of 18 and 50 and diagnosed with Friedreich's ataxia? In this study, researchers are testing a new medication, gene therapy, to treat cardiomyopathy associated with Friedreich's ataxia, and you may be able to participate if you are not taking any corticosteroids or immunosuppressive medications to treat Friedreich's ataxia. This study is taking place in New York City, New York.

Do you or a family member have a history of heart failure? This study will test if you have hereditary cardiac amyloidosis (hATTR-CA) with or without symptoms and identify changes in your body that may cause the disease to progress. To participate in this study, you should be 30 to 80 years old and have heart failure, or a family member with heart failure. The study is recruiting in New York City; Cleveland, Ohio; and Dallas, Texas.

Are you and adult diagnosed with hypertrophic cardiomyopathy? If so, you may be able to participate in this study where researchers are studying whether exercise helps cardiomyopathy symptoms. You may be able to participate if you are between 18 and 80, have cardiomyopathy, and are able to participate in a 24-week moderate exercise training program. The study is taking place in San Francisco, California.

Have you taken or will you soon be taking chemotherapy for cancer? This study is observing participants who developed chemotherapy-related cardiac toxicity (CRCT) or are susceptible to developing CRCT before chemotherapy begins. To participate in the study, you must be 18 years old or older and either have taken chemotherapy with or without CRCT diagnosis or will initiate chemotherapy. The study is located in Scottsdale, Arizona, and Jacksonville, Florida.

Have you been diagnosed with nonobstructive hypertrophic cardiomyopathy? With nonobstructive hypertrophic cardiomyopathy the heart muscle thickens, but blood flow is not significantly blocked by this because the thickened muscle does not obstruct blood flow as it exits the chamber. This study is testing a medicine that may improve heart function and exercise abilities for patients with symptomatic nonobstructive hypertrophic cardiomyopathy. To participate in this study, you should be 18 years old or older, be able to take oral medication, and be on a stable medication therapy.

Do you have a baby with Tetralogy of Fallot? This study is testing a medicine to stimulate growth of new cells in the heart muscle. To participate in this study, your baby should be 30 to 44 days old and have Tetralogy of Fallot. This study is in New York City and Pittsburgh, Pennsylvania.

Are you a Minnesota resident with hypertrophic cardiomyopathy? This study aims to find out how common it is for people with hypertrophic cardiomyopathy to also have sleep apnea. Hypertrophic cardiomyopathy is a disease that causes the heart muscle to thicken. Participants will also wear a heart rhythm monitor to help researchers learn whether sleep apnea is linked to arrhythmia. The study seeks healthy volunteers as well as participants in the Hypertrophic Cardiomyopathy Registry. To participate in this study, you must not have had a catheter ablation procedure to treat atrial fibrillation, had surgery to replace your heart valves, or been treated for sleep apnea. The study is located in Rochester, Minnesota.

Have you been diagnosed with peripartum cardiomyopathy and are within 5 months of your due date? This study is evaluating the effectiveness of a medicine called bromocriptine to treat peripartum cardiomyopathy, or weakness of the heart muscle that occurs during or shortly after pregnancy. To participate in this study, you must be at least 18 years old, diagnosed with peripartum cardiomyopathy, and within 5 months of your delivery date. This study takes place in Pittsburgh, Pennsylvania.