Clinical Trials

Are you an adult with ischemic or non-ischemic cardiomyopathy? This observational study will group and follow patients at a higher risk for sudden cardiac death (SCD) who receive an implantable cardioverter defibrillator (ICD) pulse generator replacement as a prevention measure. The study hypothesizes that abnormalities of the heart, some of which are genetically determined, can be used to identify patients at high risk of SCD. To participate in this study, you must be between 18 and 85 years old and have ischemic or non-ischemic cardiomyopathy. You must also be getting your initial ICD implant for primary prevention or a programmed generator replacement if the ICD was originally implanted for SCD primary prevention. The study takes place in Baltimore, Maryland; Richmond, Virginia; and Washington, DC.

Are you an adult with ischemic cardiomyopathy? This study is investigating ways to prevent sudden cardiac arrest in people with ischemic cardiomyopathy. Researchers in this study are also working to determine which patients could benefit from an implantable cardioverter defibrillator, a device that is connected to the heart that can detect and stop irregular heartbeats called arrythmias. To participate in this study, you must be 18 years old or older and have ischemic cardiomyopathy. This study takes place in Buffalo, New York.

Are you a woman who is postmenopausal or a man older than 65? This study will investigate the effects of oral progesterone for older women and testosterone for older men on QT intervals. QT intervals that are increased by medicine can lead to dangerous heart rhythm problems. Researchers hope to learn more about why this happens and how to deliver safer doses. This study is located in Indianapolis, Indiana.

Are you scheduled for open-heart surgery for your aortic valve? This study aims to look at changes in inflammation and gene activity while surgery patients are on a heart-lung bypass machine. To participate in this study, you must be at least 20 years old and be scheduled for aortic valve surgery, either with or without coronary artery bypass grafting (CABG). This study is located in Boston, Massachusetts.

Did you develop atrial fibrillation after coronary artery bypass graft (CABG) surgery? Did you develop atrial fibrillation after a coronary artery bypass grafting (CABG) surgery? This study is looking at how well oral anticoagulation medicines work to prevent complications, such as blood clots and heart attack, for patients who experience post-operative atrial fibrillation (POAF). This study is in multiple locations around the country.

Do you have coronary heart disease, and are you interested in helping researchers improve how they treat and prevent this condition? This study is exploring new risk factors that may allow for more people with heart disease to get approved for an implantable cardioverter defibrillator (ICD), a device that can detect and stop irregular heartbeats. To participate in this study, you must be 18 years old or older and already have or be eligible for an ICD. This study takes place in Buffalo, New York.

Are you an adult with polycythemia vera or thrombocytosis? This study aims to find a new treatment or cure for polycythemia vera and thrombocytosis by locating genes and their changes, or mutations, that may contribute to these disorders. To participate in this study, you must have polycythemia vera with elevated hemoglobin (higher than 18 in men and 16 in women) or thrombocytosis with an elevated platelet count (higher than 450,000). This study takes place in Salt Lake City, Utah.