Clinical Trials

This is a multicenter, randomized, placebo-controlled, sequential dose-escalating, double-masked, safety study of sildenafil in premature infants with severe bronchopulmonary dysplasia,

The purpose of this study is to identify the optimal deimplementation strategies for an overused practice: continuous pulse oximetry monitoring of children hospitalized with bronchiolitis who are not receiving supplemental oxygen.

This study's objective is to identify and test pragmatic and sustainable strategies for implementing a multi-condition clinical pathway intervention for children hospitalized with asthma, pneumonia, or bronchiolitis in community hospitals.

This is a multicenter, randomized, placebo-controlled, sequential dose-escalating, double-masked, safety study of sildenafil in premature infants with severe bronchopulmonary dysplasia (BPD).

study is a feasibility pilot study to help us get information to design a larger trial of diuretic management for bronchopulmonary dysplasia.

Do you have COPD? This study will be looking for genes that may play a role in the development of COPD by looking at the blood from patients who have COPD, as well as the blood from those patients’ family members. To participate in this study, you must be 52 years old or younger and must not be pregnant or have other serious lung diseases such as lung cancer. This study will be conducted in Boston, Massachusetts.

Are you a healthy adult or someone with a history of lung infections such as pneumonia or bronchitis? This study aims to compare fluid and tissue samples from the nose and lungs of healthy adults with people who have a lung disease. Researchers hope to learn why some people are more susceptible to certain infections. This study is located at the NIH Clinical Center in Bethesda, Maryland.

Health organizations recommend exercise in an intensity based manner to promote cardiovascular adaptation and prevent disease. Metformin is a common anti-diabetes medication that reduces future type 2 diabetes and cardiovascular disease (CVD) risk. However, the optimal dose of exercise to be combined with metformin for vascular health remains unknown. The purpose of this study is to evaluate whether combining high or low intensity exercise with metformin has the potential to outperform either exercise intensity alone on blood flow across the arterial tree as well as impact insulin action in individuals with metabolic syndrome.

Do you have metabolic syndrome? This trial is testing whether low-intensity exercise or high-intensity exercise works best to lower the risk of heart and blood vessel diseases in people who have metabolic syndrome and are taking a medicine called metformin to treat high blood sugar levels. To participate in this study, you must be between 40 and 80 years old and diagnosed with metabolic syndrome but not type 2 diabetes. This study takes place in New Brunswick, New Jersey.

Do you or your child have overweight or obesity? This study aims to find effective ways to prevent and treat obesity and metabolic syndrome in African American communities. The study will test the effectiveness of a family-based comprehensive health and fitness programs involving community health workers. Participants must be 12 years old or older and African American and have overweight or obesity. This study takes place in Charleston, South Carolina.