Find NHLBI Clinical Trials

Search selected NHLBI-supported clinical trials and observational studies by condition, location, or age group. You can also view the complete list of NHLBI-funded studies at ClinicalTrials.gov.

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Showing 1 - 9 out of 9 results
Recruiting
The Bashir™ Endovascular Catheter has been designed to administer therapeutic agents in the peripheral vasculature. Because of the unique design of the catheter, with its six expandable infusion limbs, the Bashir™ Endovascular Catheter has the ability to: 1. Create a much larger central channel for blood flow, thereby utilizing the body's own endogenous fibrinolytic agents to lyse the clot, and 2. Greatly enhance the radial dispersion of a catheter-administered thrombolytic agent throughout the thrombus. Expansion of the multiple arms of the basket in the infusion catheter causes fissuring of the clot. The net result is that a greater surface area of clot is exposed to both endogenous and exogenously administered lytic agents, thereby promoting clot dissolution.
Adult, Older Adult
Recruiting
New York
Do you or your child have a platelet, bleeding, or white blood cell disorder? This study is looking at people who have platelet or other blood disorders. The researchers will use a blood sample to look for problems with platelets and a possible genetic cause in the participant’s DNA or RNA. To participate in this study, you must be a child or adult who either is healthy or has a platelet disorder, coagulation disorder, or white blood cell disorder. This study is located in New York, New York.
All Ages
Accepting Healthy Volunteers
Recruiting
Florida
Are you an adult who does not have high blood pressure and is interested in research? This study will investigate how the brain regulates the body’s response to stress and how infection with HIV or pre-hypertension affects regulation. Your heart and brain activity will be measured while you are at rest, during a mentally stressful task, and while you feel angry. The study will also test whether a breathing exercise improves regulation. People with and without HIV and pre-hypertension will be included. To participate in this study, you must be between 21 and 65 years old and not have high blood pressure. This study is located in Miami, Florida.
Adult, Older Adult
Accepting Healthy Volunteers
Recruiting
Wisconsin
Do you have a high-risk pregnancy? This study will investigate the use of a non-invasive scan called fetal magnetocardiography to detect potential problems in the fetus in five high-risk pregnancy conditions associated with stillbirth. The scan is normally used to look at fetal heart rhythms. To participate in this study, you must be at least 18 years old and pregnant with one of the following: having a stillbirth in a previous pregnancy, carrying identical twins, or having a fetus that has been diagnosed with major congenital heart disease, fetal hydrops, or fetal gastroschisis. This study takes place in Madison and Milwaukee, Wisconsin.
Adult, Older Adult
Female
Recruiting
Indiana
Are you a woman who is postmenopausal or a man older than 65? This study will investigate the effects of oral progesterone for older women and testosterone for older men on QT intervals. QT intervals that are increased by medicine can lead to dangerous heart rhythm problems. Researchers hope to learn more about why this happens and how to deliver safer doses. This study is located in Indianapolis, Indiana.
Adult, Older Adult
Accepting Healthy Volunteers
Recruiting
Maryland
Do you have a heart or blood vessel disease, such as peripheral artery disease? This study aims to collect data and samples from people who have a heart or blood vessel disease. This may include blood tests, ultrasound exams, and heart and lung tests. Family members and healthy people may also participate. The results may help researchers better understand PAD and other heart and blood vessel diseases. Participants must be at least 2 years old. Women who are pregnant may not take part in some study activities. This study is located in Bethesda, Maryland.
All Ages
Accepting Healthy Volunteers
Recruiting
Maryland
Do you or a first-degree relative have a condition that raises the risk of heart disease? This study aims to test the heart and lung function of people who have a genetic or metabolic disease that raises their risk of heart disease. Participants in this study must be between 2 and 100 years old. This study is located in Bethesda, Maryland.
All Ages
Accepting Healthy Volunteers
Recruiting
Georgia
Are you an adult who has PAD and difficulty walking? This study is testing whether a medicine that helps the body make more white blood cells can, along with walking exercise, improve symptoms and blood flow in people who have PAD. To participate in this study, you must be between 21 and 80 years old and have PAD. Women must not be pregnant and must use birth control or have been surgically sterilized if they still have menstrual periods. This study is located in Atlanta, Georgia.
Adult, Older Adult
Recruiting
Are you an adult who has PAD and overweight or obesity? This study aims to learn whether participating in an exercise program with a weight loss program reduces PAD signs and symptoms more than an exercise program alone. To participate, you must be between 18 and 85 years old, have PAD, and have a body mass index (BMI) greater than 28 but less than 45. Participants must also be willing to use a smartphone and attend weekly study sessions. This study is located in Evanston, Illinois; New Orleans, Louisiana; and Minneapolis, Minnesota.
Adult, Older Adult