Clinical Trials

The Investigators will test the hypothesis that 2-HOBA will reduce modification of HDL and LDL and improve HDL function in humans with heterozygous FH.

This study will assess differences in inflammatory proteins, lipoprotein composition, cholesterol efflux and HDL-proteome in moderate-to-severe pediatric psoriasis who at baseline begin systemically administered therapy vs: a) healthy controls; and b) patients with milder psoriasis.

This is a prospective, interventional, cohort study, meaning that researchers will follow and observe a group of enrolled study participants over a period of time (one to two months) to gather information and record any developments of the outcomes in question.

The purpose of this study is to improve cholesterol treatment among blood donors with FH (Familial Hypercholesterolemia).

Do you or does your child have a lipid disorder and want to improve future diagnosis and treatment? This study is exploring how different diagnostic tests can help us understand how lipid disorders, including high blood cholesterol, affect the body. Information from this study may help improve the way lipid disorders are diagnosed or treated in the future. To participate, you or your child must be at least 2 years old. The study is being conducted in Bethesda, Maryland.

Do you take medicine for high blood pressure or high blood cholesterol? This study will test a program that asks pharmacists to reach out to patients who have high blood pressure, high blood cholesterol, or diabetes and help them stick to their plans for taking and refilling their medicines as prescribed. To participate in this study, you must be between 18 and 75 years old. The study location is in Bloomington, Minnesota.

Do you or your child have obesity and high blood cholesterol or triglycerides? This study is testing the use of a statin in young people to see whether early treatment of high blood cholesterol can affect the risk of developing plaque in blood vessels. Participants in this study must be age 10-17, have a body mass index (BMI) in the obese range, be fluent in English, and not be pregnant.

Are you living with HIV and high blood cholesterol or high blood pressure? This study is evaluating a nurse-led reminder system to help people who have HIV stay on track with their heart medicines. Participants will have four visits with a nurse, who will help them manage their medicine schedule with telephone reminders. To participate in this study, you must be at least 18 years old; have HIV, high blood cholesterol, or high blood pressure or be taking medicines to manage these conditions; and have access to a telephone. This study is located in Cleveland, Ohio, and Durham, North Carolina.

Do you or your child have dyslipidemia? This study is exploring how different diagnostic tests can help us understand how lipid disorders, including high blood cholesterol and high blood triglycerides, affect the body. Information from this study may help improve the way lipid disorders are diagnosed or treated in the future. Participants in this study must be at least 2 years old. The study is being conducted in Bethesda, Maryland.

Are you an adult who is healthy or has problems with the level of cholesterol or other lipids in the blood? This study is gathering information on the risk factors for very high or very low levels of lipids, or fats, in the blood. Researchers will collect participants’ demographic information, medical history, and blood samples. To participate in this study, you must be at least 18 years old. This study takes place in Dallas, Texas.