Clinical Trials

Are you a woman who is postmenopausal or a man older than 65? This study will investigate the effects of oral progesterone for older women and testosterone for older men on QT intervals. QT intervals that are increased by medicine can lead to dangerous heart rhythm problems. Researchers hope to learn more about why this happens and how to deliver safer doses. This study is located in Indianapolis, Indiana.

Is your child having otolaryngologic surgery with anesthesia? Children with Down syndrome often experience dangerously low heart rates when they receive anesthesia for procedures. This study will look at children who have Down syndrome and children who do not to monitor their heart rate during this type of procedure. Participants in this study must be between 1 and 8 years old. This study is located in Cincinnati, Ohio.

Are you an adult with heart failure and right bundle branch block (RBBB)? This study will evaluate the effectiveness and benefit of His-bundle-pacing enhanced cardiac resynchronization therapy (His-CRT) versus cardiac resynchronization therapy (BiV-CRT). This study is located in Rochester, New York.

Are you a female between 18 and 55 years old who has postural tachycardia syndrome (POTS)? This study is looking at the sympathetic nervous system and its effect on the increased heart rate and dizziness upon standing that people with POTS experience. This study is located in Nashville, Tennessee.

Are you an adult with postural tachycardia syndrome (POTS)? This study is investigating whether an antibody-mediated autoimmune reaction lead to the dizziness and other symptoms of POTS. The study will also test whether vagal stimulation improves POTS symptoms. This study takes place in Oklahoma City, Oklahoma.

Are you an adult with cardiomyopathy who is eligible for a left ventricular assist device (LVAD)? This study is investigating whether a ventricular arrhythmia (VTA) ablation at the same time that an LVAD is implanted lowers the risk of VTA after surgery. This study is located in Rochester, New York.

Are you at least 12 weeks pregnant? This study is recruiting women with healthy pregnancies and women who have experienced an abnormal fetal heart rate or rhythm. Researchers are evaluating fetal magnetocardiography as a new tool to improve the study of fetal heart rate and rhythm. This study is located in Madison, Wisconsin.

The purpose of this project is to test sleep reactivity as an independent cause of Shift Work Disorder (SWD). The primary hypothesis is that those with high sleep reactivity will show persistent SWD symptoms after experimental reduction of circadian misalignment, which will then be mitigated with CBT.

Shift work increases the risk for diabetes possibly due to the adverse metabolic effects of circadian misalignment. As shift work is not foreseen to disappear, the development of individually-targeted therapies for metabolic health in these vulnerable shift workers is urgently needed. This research will determine whether our dietary intervention can mitigate the adverse metabolic effects of circadian misalignment, which may help in the design of evidence-based dietary interventions to improve the metabolic health in shift workers.

This study will leverage state-of-the-art, 24-hour behavior assessment in each trimester of pregnancy and examine associations with adverse pregnancy outcomes to inform guidelines and future interventions designed to improve women's pregnancy and long-term cardiovascular health.