Clinical Trials

Are you a woman who is postmenopausal or a man older than 65? This study will investigate the effects of oral progesterone for older women and testosterone for older men on QT intervals. QT intervals that are increased by medicine can lead to dangerous heart rhythm problems. Researchers hope to learn more about why this happens and how to deliver safer doses. This study is located in Indianapolis, Indiana.

Is your child having otolaryngologic surgery with anesthesia? Children with Down syndrome often experience dangerously low heart rates when they receive anesthesia for procedures. This study will look at children who have Down syndrome and children who do not to monitor their heart rate during this type of procedure. Participants in this study must be between 1 and 8 years old. This study is located in Cincinnati, Ohio.

Are you an adult with heart failure and right bundle branch block (RBBB)? This study will evaluate the effectiveness and benefit of His-bundle-pacing enhanced cardiac resynchronization therapy (His-CRT) versus cardiac resynchronization therapy (BiV-CRT). This study is located in Rochester, New York.

Are you a female between 18 and 55 years old who has postural tachycardia syndrome (POTS)? This study is looking at the sympathetic nervous system and its effect on the increased heart rate and dizziness upon standing that people with POTS experience. This study is located in Nashville, Tennessee.

Are you an adult with postural tachycardia syndrome (POTS)? This study is investigating whether an antibody-mediated autoimmune reaction lead to the dizziness and other symptoms of POTS. The study will also test whether vagal stimulation improves POTS symptoms. This study takes place in Oklahoma City, Oklahoma.

Are you an adult with cardiomyopathy who is eligible for a left ventricular assist device (LVAD)? This study is investigating whether a ventricular arrhythmia (VTA) ablation at the same time that an LVAD is implanted lowers the risk of VTA after surgery. This study is located in Rochester, New York.

Are you at least 12 weeks pregnant? This study is recruiting women with healthy pregnancies and women who have experienced an abnormal fetal heart rate or rhythm. Researchers are evaluating fetal magnetocardiography as a new tool to improve the study of fetal heart rate and rhythm. This study is located in Madison, Wisconsin.

Do you have a heart or blood vessel disease, such as peripheral artery disease? This study aims to collect data and samples from people who have a heart or blood vessel disease. This may include blood tests, ultrasound exams, and heart and lung tests. Family members and healthy people may also participate. The results may help researchers better understand PAD and other heart and blood vessel diseases. Participants must be at least 2 years old. Women who are pregnant may not take part in some study activities. This study is located in Bethesda, Maryland.

Do you or a first-degree relative have a condition that raises the risk of heart disease? This study aims to test the heart and lung function of people who have a genetic or metabolic disease that raises their risk of heart disease. Participants in this study must be between 2 and 100 years old. This study is located in Bethesda, Maryland.

Are you an adult who has PAD and difficulty walking? This study is testing whether a medicine that helps the body make more white blood cells can, along with walking exercise, improve symptoms and blood flow in people who have PAD. To participate in this study, you must be between 21 and 80 years old and have PAD. Women must not be pregnant and must use birth control or have been surgically sterilized if they still have menstrual periods. This study is located in Atlanta, Georgia.