Clinical Trials

This study is testing whether a medicine called metformin can help treat aortic aneurisms in the abdomen. The study will use imaging tests to examine whether metformin can help prevent these aortic aneurisms from getting bigger. To participate in this study, you must be 55 to 90 years old and diagnosed with an abdominal aortic aneurism. This study takes place in Stanford, California.

Do you have coronary heart disease, and are you interested in helping researchers improve how they treat and prevent this condition? This study is exploring new risk factors that may allow for more people with heart disease to get approved for an implantable cardioverter defibrillator (ICD), a device that can detect and stop irregular heartbeats. To participate in this study, you must be 18 years old or older and already have or be eligible for an ICD. This study takes place in Buffalo, New York.

Have you been diagnosed with orthostatic intolerance? This study aims to find out how the body’s regulation of basic functions, such as heart rate and blood pressure, is altered in people who have orthostatic intolerance. This condition, which has an unknown cause, is characterized by a racing heartbeat, dizziness, lightheadedness, and other symptoms that occur when a person stands up. To participate in this study, you must be between 18 and 80 years old and have orthostatic intolerance. This study is located in Nashville, Tennessee.

Do you have low blood pressure due to primary autonomic failure from a medical condition such as Parkinson disease, multiple system atrophy, or pure autonomic failure? Autonomic failure is caused by problems with a part of the nervous system called the autonomic nervous system. People with this condition can suffer debilitating low blood pressure upon standing. This study is testing the use of compression garments compared with a medicine called midodrine to improve blood pressure. To participate in this study, you must be between 18 and 80 years old and have low blood pressure when standing. This study takes place in Nashville, Tennessee.

Have you been diagnosed with LAM? This study is trying to understand the genes and proteins that are responsible for causing lung damage in patients with LAM. To participate in this study, you must be between 16 and 99 years old and diagnosed with LAM. This study is located in Bethesda, Maryland.

Are you an adult female who has been diagnosed with LAM? This study is examining which delivery method of albuterol—inhaled or nebulizer—is better at improving lung function in adult women who have LAM. This study is located in Bethesda, Maryland.

Do you have LAM and would be willing to help research? This study aims to identify the right dose of sirolimus to treat people who have LAM. To participate in this study, you must be female, between 18 and 90 years old, and diagnosed with LAM. This study is located in Bethesda, Maryland.

Are you an adult woman who would like to help develop methods to prevent the worsening of LAM? This study aims to discover whether earlier and longer treatment with a lower dose of sirolimus can help prevent LAM from getting worse over time. To participate in this study, you must be female, be at least 18 years old, and have been diagnosed with LAM. This study is located in Atlanta, Georgia; Boston, Massachusetts; Chicago, Illinois; Cincinnati, Ohio; Denver, Colorado; Nashville, Tennessee; Palo Alto, California; Philadelphia, Pennsylvania; and Seattle, Washington.