Clinical Trials and Studies

Are you recovering after treatment for ARDS? This study aims to test a rehabilitation intervention with patients who are recovering from ARDS and have symptoms of depression. The intervention includes periodic visits from physical and occupational therapists, an exercise regimen, and regular check-ins by phone. To participate in this study, you must be at least 18 years old and recovering at home after hospital treatment for ARDS or another type of acute respiratory failure. This study is located in Baltimore, Maryland.

Are you interested in helping researchers learn more about how inflammation and diseases of the blood vessels start? Diseases related to the immune system, blood clots, and blood vessels are interrelated. This study is trying to understand how these diseases start and what happens in the different organs in people with these diseases. To participate in this study, you or your child should be 5 years old or older and be healthy or have an autoimmune disease, or problems with blood clots or blood vessels. This study is in Bethesda, Maryland.

DIVA is a pragmatic randomized clinical trial (RCT) to determine: among (P) preterm infants born 24-27 6/7 weeks gestation undergoing extubation from mechanical ventilation, whether (I) Non-invasive neurally adjusted ventilatory assist (NIV-NAVA) (C) compared with Non-synchronized nasal intermittent positive pressure ventilation (NS-NIPPV), will reduce the incidence of (O) extubation failure within (T) 5 days (120 hours) of extubation.

Some patients with rheumatoid arthritis develop a type of scarring in the lungs that gets progressively worse. This is called “rheumatoid arthritis associated interstitial lung disease (RA-ILD)”. This study aims to understand the progression of RA-ILD using a combination of clinical, radiological, and blood measurements. Participants will have annual follow-ups for 2 years and a clinic visit every 4 months. Patients must be 18 years old or older to participate in the study. The study is being conducted at multiple sites in the United States.

Did you have COVID-19 and are you now experiencing increased tiredness? Patients who had COVID-19 may experience several persistent clinical symptoms called Long COVID. NIH is funding research programs that investigate the biological mechanisms of Long COVID and potential therapeutic strategies.

Did you have COVID-19 and are you now experiencing increased tiredness? This study is testing if increasing activities gradually under supervision will improve an individual’s quality of life, exercise capacity, and ability to do daily activities. To participate in this study, you should be 18 years old or older, previously have had COVID-19, and have some limitation in your ability to exercise or do normal activities. This study is based in Durham, North Carolina, with multiple sites throughout the United States.

Did you have COVID-19 and are you now experiencing increased tiredness? Patients who had COVID-19 may experience several persistent clinical symptoms called Long COVID. NIH is funding research programs that investigate the biological mechanisms of Long COVID and potential therapeutic strategies.

Did you have COVID-19 and are you now experiencing increased tiredness? This study is testing if a program for heart rehabilitation will improve an individual’s quality of life, exercise capacity, and ability to do daily activities. To participate in this study, you should be 18 years old or older, previously have had COVID-19, and have some limitation in your ability to exercise or do normal activities. This study is based in Durham, North Carolina, with multiple sites throughout the United States.

Did you have COVID-19 and are you now experiencing increased tiredness? Patients who had COVID-19 may experience several persistent clinical symptoms called Long COVID. NIH is funding research programs that investigate the biological mechanisms of Long COVID and potential therapeutic strategies. Did you have COVID-19 and are you now experiencing increased tiredness? This study is testing if an interventional exercise will improve an individual’s quality of life, exercise capacity, and ability to do daily activities. Individuals who are 18 years old or older, have had COVID-19, and have some limitation in their ability to exercise or do normal activities are encouraged to participate in this study. This study has multiple locations across the United States.

Are you an adult who has idiopathic pulmonary fibrosis or an advanced lung cancer? This study aims to see whether a new imaging dye for positron emission tomography (PET) is effective at looking at fibrosis in lung cancer and idiopathic pulmonary fibrosis (IPF). Participants will be given the imaging dye and then receive a PET scan. To participate in this study, you must either be between 18 and 80 years old and have lung cancer or be a healthy volunteer or be between 50 and 80 years old and have IPF. This study is located in Boston, Massachusetts.

Do you have a high-risk pregnancy? This study will investigate the use of a non-invasive scan called fetal magnetocardiography to detect potential problems in the fetus in five high-risk pregnancy conditions associated with stillbirth. The scan is normally used to look at fetal heart rhythms. To participate in this study, you must be at least 18 years old and pregnant with one of the following: having a stillbirth in a previous pregnancy, carrying identical twins, or having a fetus that has been diagnosed with major congenital heart disease, fetal hydrops, or fetal gastroschisis. This study takes place in Madison and Milwaukee, Wisconsin.

Are you a woman who is postmenopausal or a man older than 65? This study will investigate the effects of oral progesterone for older women and testosterone for older men on QT intervals. QT intervals that are increased by medicine can lead to dangerous heart rhythm problems. Researchers hope to learn more about why this happens and how to deliver safer doses. This study is located in Indianapolis, Indiana.