Find NHLBI Clinical Trials

Search selected NHLBI-supported clinical trials and observational studies by condition, location, or age group. You can also view the complete list of NHLBI-funded studies at ClinicalTrials.gov.

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Showing 1 - 10 out of 23 results
Recruiting
Do you have mitral valve disease? This clinical trial is testing different types of images taken of the heart to learn more about mitral valve disease and the best ways to treat it. You must be 60 years old to participate. The study is enrolling patients in locations in Arkansas, California, Georgia, Indiana, Louisiana, Maine, Maryland, Massachusetts, Michigan, Missouri, New York, North Carolina, Ohio, Pennsylvania, and Quebec City, Canada.
Adult, Older Adult
Recruiting
Maryland
Do you have coronary heart disease or are you healthy and would like to participate in research? This study is comparing how well two types of magnetic resonance imaging (MRI) scanners can detect different types of heart diseases, such as coronary heart disease, heart failure, congenital heart disease, and heart valve disease. The new type of MRI scanner in this study uses less energy than a traditional scanner and may be suitable for people who have metal devices in their bodies. This study is located in Bethesda, Maryland.
Adult, Older Adult
Accepting Healthy Volunteers
Recruiting
Massachusetts
Are you scheduled for open-heart surgery for your aortic valve? This study aims to look at changes in inflammation and gene activity while surgery patients are on a heart-lung bypass machine. To participate in this study, you must be at least 20 years old and be scheduled for aortic valve surgery, either with or without coronary artery bypass grafting (CABG). This study is located in Boston, Massachusetts.
Adult, Older Adult
Recruiting
Ohio
Do you or your child have a heart defect that requires a procedure called extracardiac conduit–total cavopulmonary connection (EC-TCPC)? This study is evaluating the effectiveness of a new type of graft called a tissue-engineered vascular graft for EC-TPC. Participants of this study will have this procedure and several follow-up assessments with magnetic resonance imaging (MRI) to test the performance of the graft. This study takes place in Columbus, Ohio.
All Ages
Recruiting
Are you 65 years old or older, and do you have severe primary mitral regurgitation? This condition — also called degenerative mitral regurgitation — happens when there is a problem with the mitral valve itself or its supporting tissue, leading to a leaky valve. This study is comparing the safety and effectiveness of two different ways of repairing the mitral valve: transcatheter edge-to-edge repair and surgical repair. To participate in this study, your healthcare provider must determine that you are a candidate for both mitral valve transcatheter edge-to-edge repair and surgical repair. This study takes place in multiple locations across the United States and Canada.
Older Adult
Recruiting
Georgia
Do you have cardiomyopathy that has led to moderate or severe mitral regurgitation? This study is exploring the best surgical technique to repair mitral regurgitation by comparing two procedures called undersizing mitral annuloplasty (UMA) and papillary muscle approximation (PMA). A UMA is a common procedure that involves implanting a prosthetic ring onto the mitral valve to stop the valve from leaking. A PMA is a newer technique in which a suture draws together the two muscles that connect the mitral valve to the heart muscle prior to performing UMA. To participate in this study, you must be 18 years old or older and have never had a mitral valve repair procedure. This study takes place in Atlanta, Georgia.
Adult, Older Adult
Recruiting
Michigan
Have you experienced a cardiac event in the past 6 months? This study assesses the efficacy of combining center-based and remote- or home-based cardiac rehabilitation sessions. Many patients who require cardiac rehabilitation, including those with angina myocardial infarction, heart failure, heart valve disease, and coronary heart (artery) disease, do not complete the necessary amount of rehabilitation sessions when done in a center-based environment. Researchers are investigating whether a combination approach will help. To participate in this study, you must be between 18 and 85 years old. This study takes place in Detroit, Michigan.
Adult, Older Adult
Recruiting
Pennsylvania
Do you have high blood pressure, high A1C levels, or have overweight or obesity? Researchers are testing if a program helps increase physical activity for people at risk of cardiovascular disease. Participants will receive remote coaching and wear a physical activity tracker. To join, you must be 40 to 70 years old and can access the internet. The study is taking place in Pittsburgh, Pennsylvania.
Adult, Older Adult
Accepting Healthy Volunteers
Recruiting
Texas
Are you a Hispanic father with a child between 5 and 11 years old? If so, would you be interested in learning how to prevent obesity for you and your child? Researchers are studying whether a father-child together program helps Hispanic dads and their children learn and use healthy behaviors to prevent obesity. You may be able to join if you are 65 or younger and have a child who is between 5 and 11 years old. Stepfathers, grandfathers, uncles, or older brothers may be able to join as well. The study is taking place in Houston, Texas.
All Ages
Accepting Healthy Volunteers
Recruiting
Kentucky
Do you live in Appalachian Kentucky? Researchers will be using a phone app and incentives to provide health coaching. Participants will be encouraged to eat more fruits and vegetables and reduce saturated fats and screen time. They will also monitor your physical activity using a motion device and help you become more active. To join, you must be 18 years or older. The study is taking place in Benham, Kentucky.
Adult, Older Adult
Accepting Healthy Volunteers