Clinical Trials

The Dilated Cardiomyopathy-Cardiac Magnetic Resonance (DCM-CMR) Study is an ancillary study from the parent study, DCM Precision Medicine Study. The rationale for the DCM-CMR study is to leverage cardiac magnetic resonance (CMR) imaging to detect earliest findings of DCM in the at-risk family members enrolled into the parent study.

This study is designed to determine the efficacy and safety of colchicine in patients with chronic kidney disease.

The Dilated Cardiomyopathy-Cardiac Magnetic Resonance (DCM-CMR) Study is an ancillary study from the parent study, DCM Precision Medicine Study. The rationale for the DCM-CMR study is to leverage cardiac magnetic resonance (CMR) imaging to detect earliest findings of DCM in the at-risk family members enrolled into the parent study.

In this study, the investigators will recruit a cohort of elderly Black and Hispanic patients with heart failure to define the number of patients who have cardiac amyloidosis by utilizing highly sensitive heart imaging and blood tests.

The EXCITE-HCM study is designed to evaluate the effect of moderate intensity exercise training versus usual physical activity on the improvement of HCM-related symptoms and cardiac function. Patients will be followed during a period of 24 weeks and assessments as physical examination, questionnaires, 12 lead ECGs, biomarker levels, echocardiogram, Cardiac Magnetic resonance, PET and CPET will be performed to evaluate their response to the intervention.

The goal of the current research is to develop personalized risk prediction for functional mitral regurgitation (FMR) patients through explainable unsupervised phenomapping enriched with advanced cardiac magnetic resonance (CMR) imaging biomarkers, and to determine the CMR predictors of reverse remodeling following modern therapies for FMR.

Are you a Minnesota resident with hypertrophic cardiomyopathy? This study aims to find out how common it is for people with hypertrophic cardiomyopathy to also have sleep apnea. Hypertrophic cardiomyopathy is a disease that causes the heart muscle to thicken. Participants will also wear a heart rhythm monitor to help researchers learn whether sleep apnea is linked to arrhythmia. The study seeks healthy volunteers as well as participants in the Hypertrophic Cardiomyopathy Registry. To participate in this study, you must not have had a catheter ablation procedure to treat atrial fibrillation, had surgery to replace your heart valves, or been treated for sleep apnea. The study is located in Rochester, Minnesota.

Have you been diagnosed with peripartum cardiomyopathy and are within 5 months of your due date? This study is evaluating the effectiveness of a medicine called bromocriptine to treat peripartum cardiomyopathy, or weakness of the heart muscle that occurs during or shortly after pregnancy. To participate in this study, you must be at least 18 years old, diagnosed with peripartum cardiomyopathy, and within 5 months of your delivery date. This study takes place in Pittsburgh, Pennsylvania.

Have you recently been diagnosed with Takotsubo Syndrome? This study aims to investigate the short- and long-term effects of takotsubo syndrome, sometimes referred to as broken heart syndrome. Usually, takotsubo syndrome is a temporary heart condition that is caused by either emotional or physical stress. To participate in this study, you must have a new diagnosis of takotsubo syndrome and be at least 18 years old. This study takes place in Providence, Rhode Island.

Are you an adult with ischemic cardiomyopathy? This study is investigating ways to prevent sudden cardiac arrest in people with ischemic cardiomyopathy. Researchers in this study are also working to determine which patients could benefit from an implantable cardioverter defibrillator, a device that is connected to the heart that can detect and stop irregular heartbeats called arrythmias. To participate in this study, you must be 18 years old or older and have ischemic cardiomyopathy. This study takes place in Buffalo, New York.