Clinical Trials and Studies

This study is testing whether a medicine called metformin can help treat aortic aneurisms in the abdomen. The study will use imaging tests to examine whether metformin can help prevent these aortic aneurisms from getting bigger. To participate in this study, you must be 55 to 90 years old and diagnosed with an abdominal aortic aneurism. This study takes place in Stanford, California.

The study is to investigate that the worsening orthostatic tachycardia and symptoms after glucose ingestion in POTS patients are due to a greater increase in splanchnic venous capacitance and excessive blood pooling during an orthostatic challenge.

Have you taken or will you soon be taking chemotherapy for cancer? This study is observing participants who developed chemotherapy-related cardiac toxicity (CRCT) or are susceptible to developing CRCT before chemotherapy begins. To participate in the study, you must be 18 years old or older and either have taken chemotherapy with or without CRCT diagnosis or will initiate chemotherapy. The study is located in Scottsdale, Arizona, and Jacksonville, Florida.

Are you interested in helping researchers learn more about how inflammation and diseases of the blood vessels start? Diseases related to the immune system, blood clots, and blood vessels are interrelated. This study is trying to understand how these diseases start and what happens in the different organs in people with these diseases. To participate in this study, you or your child should be 5 years old or older and be healthy or have an autoimmune disease, or problems with blood clots or blood vessels. This study is in Bethesda, Maryland.

Do you have cholesterol deposits in your heart arteries and you don’t take medicine to lower your cholesterol? This study is educating people with cholesterol deposits in their heart about the importance of taking medicines to lower cholesterol to prevent heart attacks and other heart diseases. To participate in this study, you should be 18 to 75 years old and have heart disease. This study is in Durham, North Carolina.

Do you have a heart or blood vessel disease, such as peripheral artery disease? This study aims to collect data and samples from people who have a heart or blood vessel disease. This may include blood tests, ultrasound exams, and heart and lung tests. Family members and healthy people may also participate. The results may help researchers better understand PAD and other heart and blood vessel diseases. Participants must be at least 2 years old. Women who are pregnant may not take part in some study activities. This study is located in Bethesda, Maryland.

Do you or a first-degree relative have a condition that raises the risk of heart disease? This study aims to test the heart and lung function of people who have a genetic or metabolic disease that raises their risk of heart disease. Participants in this study must be between 2 and 100 years old. This study is located in Bethesda, Maryland.

Are you an adult who has PAD and difficulty walking? This study is testing whether a medicine that helps the body make more white blood cells can, along with walking exercise, improve symptoms and blood flow in people who have PAD. To participate in this study, you must be between 21 and 80 years old and have PAD. Women must not be pregnant and must use birth control or have been surgically sterilized if they still have menstrual periods. This study is located in Atlanta, Georgia.

Are you an adult who has PAD and overweight or obesity? This study aims to learn whether participating in an exercise program with a weight loss program reduces PAD signs and symptoms more than an exercise program alone. To participate, you must be between 18 and 85 years old, have PAD, and have a body mass index (BMI) greater than 28 but less than 45. Participants must also be willing to use a smartphone and attend weekly study sessions. This study is located in Evanston, Illinois; New Orleans, Louisiana; and Minneapolis, Minnesota.