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The mission of induced Pluripotent Stem Cells (iPSC) Core is to accelerate stem cell research by providing investigators consultation, technical services and training in human pluripotent stem cell technology. The major services that iPSC Core currently provides include (1) generation of human iPSCs from fibroblast cells, CD34+ hematopoietic stem/progenitor cells, and peripheral blood mononuclear cells (PBMCs) using non-integration methods; (2) CRISPR/Cas9 mediated human iPSC gene knockout, gene correction, and AAVS1 safe harbor transgene knockin; (3) human iPSC-cardiomyocyte (CM) differentiation. The Core also provides control iPSC lines and validated iPSC culture reagents. In addition to providing services and consultations to NIH researchers, the Core staff collaborate with investigators to work on custom and exploratory projects. Research conducted by the Core seeks to better understand the mechanisms underlying pluripotent stem cell self-renewal and differentiation to optimize culture conditions and operating procedures.