Implementation Science Branch

The Implementation Science Branch (ISB) supports research on the prevention and treatment of heart, lung, blood, and sleep disorders, through implementation research for populations and communities in real-world settings. The ISB’s goal is to support integrated and coordinated research programs that emphasize the multilevel factors associated with the successful implementation of evidence-based interventions and guidelines within clinical and community settings (e.g., worksites, communities, health systems/practitioners or schools).  A key area of focus includes implementation science that addresses the prevention and treatment of heart, lung, blood, and sleep disorders in people living with HIV. Another goal of ISB is to accelerate the integration of evidence-based genomic applications into implementation science using validated implementation research frameworks. 

Our Programs

Implementation Science and Genomics

The Implementation Science and Genomics program supports innovative methods and approaches to improve the integration of genomic discoveries into real-world settings, and to enhance precision medicine initiatives in heart, lung, blood and sleep disorders. This program also aims to accelerate the translation of evidence-based genomic findings into clinical and public health practices, offering promising opportunities for precision prevention, detection, evaluation, treatment, and control of HLBS diseases and disorders for diverse populations. Additionally, the program supports research that emphasizes the use of validated implementation research frameworks to explore the adoption, scale-up, and greater use of clinical practice guidelines when available for genetic and rare diseases, including sickle cell disease and familial hypocholesteremia.  

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Implementation Science in Nutrition and Obesity

The Implementation Science in Nutrition and Obesity program supports implementation research that investigates the role of nutrition, physical activity, and obesity on population-level outcomes for heart, lung, blood, and sleep disorders across diverse settings. This includes research on the implementation of environmental, policy, and population-based prevention strategies to improve overall health and nutrition intake and to prevent and reduce obesity and other heart, lung, blood, and sleep disorders. Other areas of interest include research on pediatric, adolescent, and underrepresented populations, as well as on the implementation of nutrition and physical activity guidelines.

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Implementation Science of Sleep and Regulation

The Implementation Science of Sleep and Regulation program supports research related to sleep-disordered breathing, the fundamental functions of sleep and circadian rhythms and airway regulation. Areas of focus include research that advances the late-stage T4 translation of effective interventions to improve behavioral and lifestyle factors and social and environmental influences that improve physical health, sleep health, airway functions, and metabolic functions and that also lower the risk of heart, lung, blood, and sleep disorders. Other research priorities include strategies to facilitate population-level implementation of evidence-based interventions to decrease the disproportionate burden of sleep, cardiopulmonary, and metabolic disorders among children, certain racial or ethnic groups, and those from certain socioeconomic backgrounds.

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Implementation Science and Health Care Innovation

The Implementation Science and Health Care Innovation program focuses on rigorous evidence review, evidence integration, and implementation research that will lead to generalizable knowledge and help accelerate innovation in healthcare delivery for the prevention and treatment of heart, lung, blood, and sleep disorders in clinical and community settings. Research includes innovative strategies, methods, tools, and technologies to quicken implementation and de-implementation research; inclusion of data from pragmatic trials; decision planning support tools for public and healthcare professions to use to overcome barriers and move toward shared decision making and risk communication. 

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Research Training and Career Development Programs in Implementation Science

Research Training and Career Development Programs in Implementation Science support sustainable scientific workforce development and research capacity development in T4 translation research and implementation science to address heart, lung, blood, and sleep disorders. A strong foundation in dissemination and implementation research, employing theories, models, frameworks, and analytic techniques to reduce research practice gaps and improve implementation outcomes, is a core aspect of this training program. Collaborations with members of the community that serve diverse communities to enhance context-sensitive research designs in the successful implementation of evidence-based practices are emphasized. Focus areas for this program include theory, implementation, and evaluation approaches; creating partnerships with multilevel, transdisciplinary research teams; using research design, methods, and analyses appropriate for implementation; and conducting research at different and multiple levels of intervention (e.g., clinical, community, policy) and across health care, public health, and community settings. View current NHLBI training and career development opportunities.

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