NEWS & EVENTS
viles of blood
Blood Diagnostics Working Group - Blood Diagnostics: Blood will tell!
September 22 - 23, 2016
6701 Rockledge Drive, (Conference Room 9100/9104)
Bethesda, MD 20892
Description

Recent advances in omic tools-(genomics, proteomics, transcriptomics and metabolomics and their critical metabolites)-have created a set of tools box that can use small blood volumes for ultra- sensitive detection of key biomarkers that will allow creation of pathophysiological molecular finger prints. This will be an easy, fast, inexpensive and sensitive tool for disease diagnostic and prediction on a Nano scale. One can use blood diseases as pilots to explore such technologies. How early can the technology enable detect and predict (for example), early onset stroke, pulmonary hypertension or a vasculopathy in SCD-Sickle cell disease or in certain BMFS-Bone marrow failure disorders, be able to predict early onset of cancers (common in these disorders) and stroke in a thrombotic event. Although the proof of concept for the technology has been shown to be available, there is an unmet need for early diagnosis. This workshop will help explore further the technologies required for creation of key markers and molecular fingerprints for an early detection.

Agenda

8:30 am
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Welcome and Opening Comments

Drs. Keith Hoots &  Pankaj Qasba

8:40 am
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Talks-15min + 10 min Q & A/Discussion (25 min each)

Session I: Lead: Garry Nolan-
Limitations and opportunities for CELL based diagnostic approaches

9:05 am
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Session I: Talks

  • Leigh Anderson (Industry perspective Proteins),
    • Status of Protein Diagnostics in Blood and Commercial Pathways Forward Including Mass Spectrometry
  • Susan Sumner (metabolites),
    • Metabolomics to deliver diagnostics- and implications of blood type for disease risks.
  • Sriram Neelamangalam (Glycobiology/sugars)
    • Glycans in blood as diagnostics: Opportunities and challenges

10:20 am -10:35 am
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Break

Break

10:35 am
-
Talks-15min + 10 min Q & A/Discussion (25 min each)

Session II Lead: John Stamatoyannopoulos-
Challenges at the interface of high throughput technologies 

11:00 am
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Session II: Talks

  • Steven Soper (nano/microfluidics),
    • Blood-based Nucleic Acid Biomarkers for Diagnosing Acute Stroke
  • Michael Heller (electrophoretic methods),
    • AC Electrokinetic Microarray Chip Device for Rapid Isolation of Cell Free DNA and Exosome Biomarkers from Blood 
  • Marc Porter (optics methods),
    • Challenges in standardizing immunoassays based on nanoparticle labeling and readout

12:15 pm -1:30 pm
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Lunch Break

Lunch Break

1:30 pm
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Talks-15min + 10 min Q & A/Discussion (25 min each)

Session 3:  Lead: Shankar Subramaniam-
Markers and mechanisms from blood constituents – implications for pathology.

1:55 pm
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Session III- Talks

  • Gabe Kwong (immune system based diagnostics),
    • Activity-based synthetic biomarkers for noninvasive monitoring of disease
  • Paul Blainey (devices for cell function),
    • Biotechnology for low-input diagnostic assays
  • Jim Heath (cancer and detection)
    • Micro-/nano-tech approaches for pulling information out of the blood

3:10 pm -3:30 pm
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Break

Break

3:10 pm - 3:30 pm
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Review and Summary of Key Challenges and Opportunities

Garry, John and Shankar

4:30 pm
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Adjourn for the day

Adjourn for the day

8:30 am - 10:00 am
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Summary Session I, II & III from Day 1

General discussion- formulate recommendations
Garry, John and Shankar

10:00 am - 10:15 am
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Break

Break

10:15 am -12:15 pm
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Round 1- Outlining White Paper & Recommendations

 Garry, John and Shankar

12:15 pm - 1:00 pm
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Lunch

Lunch

1:00 pm - 3:00 pm
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Round 2- Outlining White Paper & Recommendations

Garry, John and Shankar

3:00 pm -3:10 pm
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Final Thoughts & Adjourn