DNA methylation levels change with age. Recent studies have identified biomarkers of chronological age based on DNA methylation levels. It is not yet known whether DNA methylation age captures aspects of biological age. The paper reports that DNA methylation-derived measures of accelerated ageing are heritable traits that predict mortality independently of health status, lifestyle factors, and known genetic factors. Researchers from the NHLBI's Framingham Heart Study were among the authors of this paper.
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