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Fresh red blood cell transfusions do not help critically ill children more than older cells NIH-funded finding may alter policies at hospitals where fresh red cells are preferentially used Researchers have found that transfusions using fresh red blood cells—cells that have spent seven days or less in storage—are no more beneficial than older red...

Chris Camp recalls the early days of the HIV/AIDS epidemic, when being diagnosed as HIV positive was considered a virtual death sentence. Doctors had no medications that could really help. People with the disease often did not survive more than a year or two. Camp, now 63, says he personally lost more than 500 friends. Among them: his first husband...

Results from NIH-funded trial could extend patients’ well-being Teenagers born with a single working ventricle of the heart—a rare defect that cannot be completely corrected—showed a significant improvement in their ability to sustain moderate exercise after treatment with udenafil, a drug that helps improve blood flow, according to a new study...

The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, announced today that Adolfo Correa, M.D., Ph.D., director and principal investigator of the Jackson Heart Study (JHS), has decided to retire and step down from his leadership of the study in December 2020. Recruited to be the study’s Chief Science...

Researchers have identified 57 genetic variations of a gene strongly associated with declines in blood oxygen levels during sleep. Low oxygen levels during sleep are a clinical indicator of the severity of sleep apnea, a disorder that increases the risk of heart disease, dementia, and death. The study, published today in the American Journal of...

Initial investment aims to advance accessible and scalable candidate interventions into clinical trials within 10 years The National Institutes of Health plans to invest at least $100 million over the next four years toward an audacious goal: develop affordable, gene-based cures for sickle cell disease (SCD) and HIV. The Bill & Melinda Gates...

WHAT: Hispanics in the United States suffer from high prevalence of cardiometabolic disorders such as heart disease, stroke, and obesity, according to the Centers for Disease Control and Prevention . These chronic conditions are a top research priority for the National Heart, Lung, and Blood Institute (NHLBI), and Hispanic Heritage Month, from...

'Forward-oriented’ design might boost treatment effectiveness and broaden use Researchers at the National Institutes of Health (NIH) have developed a new and improved viral vector—a virus-based vehicle that delivers therapeutic genes—for use in gene therapy for sickle cell disease. In advanced lab tests using animal models, the new vector was up to...

The move away from high-field MRI offers promising results for the diagnosis and treatment of diseases National Institutes of Health researchers, along with researchers at Siemens, have developed a high-performance, low magnetic-field MRI system that vastly improves image quality of the lungs and other internal structures of the human body. The new...

Detailed pregnancy history, prevention strategies may hold a key to improving health outcomes Women who experience complications such as preterm births and preeclampsia during their first pregnancy are nearly twice more likely than women without complications to develop high blood pressure later in life—some as quickly as three years later...