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November 9, 2015

Large study reports results comparing two CPR methods used by EMS providers following sudden cardiac arrest

In a study published online today in the New England Journal of Medicine, researchers found that cardiopulmonary resuscitation (CPR) administered by emergency medical services (EMS) providers following sudden cardiac arrest that combines chest compressions with interruptions for ventilation resulted in longer survival times and shorter hospital stays than CPR that uses continuous chest compressions.

October 22, 2015

Large-scale genetic study may provide new insight into aging, age-related chronic diseases

WHAT:  An international team of scientists co-led by researchers from the National Heart, Lung, and Blood Institute (NHLBI) is reporting the discovery of nearly 1,500 age-related genes, most of which have not been previously identified. The study, one of the largest of its kind to explore genes associated with aging, could spark new insights into the aging process and age-related chronic diseases, including heart disease, cancer, and stroke. The findings could, for example, provide new targets for developing drugs to delay or prevent age-related diseases.

August 4, 2015

Measurement of Cholesterol Function Might Provide Link to Heart Attack Risk in Patients with Psoriasis

Scientists now report a new way to assess cholesterol that shows promise for evaluating the increased heart attack risk observed in patients with psoriasis, a common inflammatory skin disease. The new technique measures the function of high-density lipoprotein (HDL), known as “good” cholesterol, rather than HDL cholesterol concentration. The study, conducted by researchers from the National Heart Lung and Blood Institute at the National Institutes of Health (NIH), could broaden the use of the technique. The study appears in the online issue of the European Heart Journal.

July 31, 2015

NIH Seeks Comment on Agency-wide Strategic Plan

In response to a request from the Congress, NIH is developing a 5-year NIH-wide Strategic Plan to advance its mission to support research in pursuit of fundamental knowledge about the nature and behavior of living systems, and the application of that knowledge to extend healthy life and reduce illness and disability. Senior leadership and staff from all 27 Institutes, Centers, and Offices (ICOs) are contributing to the proposed direction and content of the Strategic Plan, with input from the Advisory Committee to the Director, NIH.

July 29, 2015

High-resolution 3D images reveal the muscle mitochondrial power grid

A new study overturns longstanding scientific ideas regarding how energy is distributed within muscles for powering movement. Scientists are reporting the first clear evidence that muscle cells distribute energy primarily by the rapid conduction of electrical charges through a vast, interconnected network of mitochondria—the cell’s “powerhouse”—in a way that resembles the wire grid that distributes power throughout a city. The study offers an unprecedented, detailed look at the distribution system that rapidly provides energy throughout the cell where it is needed for muscle contraction.

July 1, 2015

Largest Study of Gene Mutations in Aplastic Anemia May Help Optimize Treatment

Scientists have identified a group of genetic mutations in patients with aplastic anemia, which likely will help doctors optimize treatment for this rare and deadly blood condition. The study, appearing in the New England Journal of Medicine, could lead to tailor-made treatment plans for aplastic anemia patients as part of the emerging precision medicine movement. It is the largest study of its kind to examine gene mutations in aplastic anemia, the scientists note.

June 19, 2015

Scientists develop method of producing large quantities of selectively labeled RNA molecules

Study opens door to new opportunities in medicine and research

WHAT: Scientists have developed an efficient method of producing substantial quantities of RNA molecules with selectively labeled regions, paving the way for more advanced research and medical applications. RNA — DNA's lesser-known partner molecule — plays a significant role not only in genetic activities but in many other biological functions like enzymatic processes. It also is an important research, medical diagnostic, and therapeutic tool.

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