Thressa "Terry" Stadtman (1920-2016), a longtime researcher with NHLBI, is remembered for her pioneering studies on selenium biochemistry, the role of vitamin B12, and the synthesis of methane. Among her notable achievements: She helped discover that selenocysteine is the 21st amino acid incorporated into proteins. A brief article, published in ASBMB Today, highlights her accomplishments.
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The study Modulation of mTOR signaling as a strategy for the treatment of Pompe disease partly funded by NHBLI made the cover of the March issue of the journal EMBO Molecular Medicine. The findings might pave the way to some therapeutic interventions by identifying profound signaling defects of the mTOR gene.
There is something to be said for ‘eating your own,’ at least at the cellular level. Researchers funded by NHLBI demonstrate that autophagy, a process of cellular self-consumption, is essential for the healthy metabolism and function of haematopoietic stem cells, the rare adult stem cells, found in the bone marrow, that produce all blood cell types. The findings, published in Nature, show how autophagy, which is associated with health and longevity, contributes to maintaining the stem cells’ ability to regenerate the blood system.
Researchers partially funded by NHLBI warned that seniors sleeping more than nine hours each night could be at higher risk of dementia in later years. The study, published in the journal Neurology, shows the increased risk in people who were not used to sleep that much before. The researchers say that the need for extra sleep might be a sign of the risk of dementia, not the cause.
You don’t have to fight heart disease alone: You have a whole village by your side. “It's important to view heart health as not just the absence of heart disease but really as physical, social and mental well-being,” says George Mensah, MD, director of the NHLBI Center for Translation Research and Implementation Science (CTRIS), who keynoted the Woman’s Day and NHLBI panel that kicked off American Heart Month.
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NHLBI-funded researchers managed to reverse high blood pressure in the offspring of pregnant rats suffering from hypertension. The findings, published in the journal Hypertension, could lead to new research into prevention of mother to child transmission of various health conditions. “This study on rats sheds some light on how maternal health during pregnancy impacts long-term cardiovascular health of the offspring,” says Christine Maric-Bilkan, program officer of the NHLBI Division of Cardiovascular Sciences.
For older men with low testosterone levels, taking testosterone supplements appears to improve anemia but may increase the risk of heart disease, according to a series of new studies that provides a fuller picture of testosterone benefits and risks. One of the new studies found that men with anemia, or a deficiency of red blood cells, had their condition improve with testosterone gel supplements. Another study found that older men with low testosterone levels who used testosterone gel had a higher risk of coronary artery plaque, which is linked to heart disease. The studies were partly funded by NHLBI and published in the Journal of the American Medical Association.
Researchers partly funded by NHLBI discovered a new Twist in regeneration and muscle growth in adult mice. The Twist2 is a muscle progenitor cell and is different from the satellite cells once thought the sole contributors to muscle regeneration. The findings, published in Nature Cell Biology, were based in studies of mice.
NHLBI-funded researchers found that current formulas significantly underestimate the amount of salt and potassium that Latinos consume. The findings, published in Nature Journal of Human Hypertension, refer to the self-report measures used in the Hispanic Community Health Study/Study of Latinos, the largest cohort of Hispanics in the United States.
NHLBI’s Director, Dr. Gary Gibbons took to blackamericaweb.com to answer audience’s questions about heart health, during the American Heart Month. From cholesterol and diet to sleep apnea and supraventricular tachycardia (SVT), the questions run the gamut, showing the interests and concerns of the community.