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May 31, 2017 : JAMA Cardiology

Researchers are reporting that treating skin inflammation in people with psoriasis may have beneficial effects on underlying inflammation of the blood vessels and help reduce the risk of atherosclerosis and heart disease in these individuals.  The study, published in JAMA Cardiology, is funded by NHLBI.

MedPage Today: Can Psoriasis Tx Diminish Atherosclerosis?

May 31, 2017 : JAMA Cardiology

Reducing systolic blood pressure to levels below currently recommended targets may significantly reduce the risk of cardiovascular disease and save lives, according to a new study published in JAMA Cardiology. The study is based on a systematic review and analysis of 42 clinical trials involving 144,220 people.  It is partly funded by NHLBI.  

MedPage Today: New Review Supports Aggressive BP Targets

Medical Xpress: Findings suggest reducing target SBP to below recommended levels could significantly reduce risk

Physician’s Briefing: Reducing SBP Targets Below Current Guidelines Cuts Risk

News Medical: Reducing target systolic blood pressure lowers risk of cardiovascular disease and mortality

Science Daily: Lower targets for systolic blood pressure suggested by study

May 24, 2017 : The Atlantic

Researchers partly funded by NHLBI revealed that the Zika virus showed up in the Americas several months, perhaps even years, before anyone realized it. In the study published in the journal Nature the researchers mapped 54 complete or partial genomes of DNA of the virus in order to track its spread through the continent.

Los Angeles Times: What the DNA of the Zika virus tells scientists about its rapid spread

Wired: Virus Hunters Draw a Map of Zika’s Spread With DNA

The San Diego Union-Tribune: Zika struck Florida up to 40 times before detection

TheScientist: Tracing Zika’s Spread Through Genetics

ScienceNews: The Zika epidemic began long before anyone noticed

May 24, 2017 : The New York Times

Some people are natural knockouts, that is, they are born missing one of more genes. This presents a great opportunity to study what a specific gene does. A team of researchers partly funded by NHLBI has described more than 1,800 so-called "human knockouts" in a major study published in Nature. Another NHLBI-funded study in the  recent study in the Journal of the American College of Cardiology showed how these genetic mutations validate a new strategy for reducing cholesterol.

Science Now: Human ‘knockouts’ may reveal why some drugs fail

EurekAlert: Genetics of first-cousin marriage families show how some are protected from heart disease

ScienceNews: Gene knockouts in people provide drug safety, effectiveness clues How 1,800 Pakistanis are helping Penn scientists fight disease

More coverage 

May 23, 2017 : MedPage Today

The COPD National Action Plan, released at the American Thoracic Society International Conference meeting this week in Washington, D.C., is a detailed, patient-centered roadmap that aims to reduce the burden of the third leading cause of death.

MedicalXpress: New COPD action plan outlines strategies for improved care

EurekAlert!: ATS 2017: New COPD action plan outlines strategies for improved care

Medpage: NHLBI Unveils COPD National Action Plan

May 23, 2017 : JAMA Internal Medicine

A study partly funded by NHLBI showed that seniors aged 65 to 74 don’t benefit from taking statins as prevention against cardiovascular disease or mortality. The findings appear in the JAMA Internal MedicineNo benefit was found when a statin was given for primary prevention to older adults. Treatment recommendations should be individualized for this population,” the article concludes.

May 23, 2017 : The New York Times

Great news for chocolate lovers: Researchers are reporting a link between eating the popular treat and a lowered risk for atrial fibrillation, a type of irregular heartbeat that can lead to stroke, heart failure, and other problems.  Their study, published in Heart (BMJ), was supported by NHLBI.

CBS News: Chocolate linked to lower risk for heart condition AFib 

Fox News: A new health benefit of chocolate: reduced risk of AFib?  

Reuters: Chocolate tied to decreased risk of irregular heart rhythm 

Forbes: Chocolate May Reduce Risk Of Developing Common Heart Arrhythmia 

Newsweek: Want a Healthy Heart? Eat Chocolate, New Study Says

Live Science:  Sweet Therapy: Chocolate May Help Prevent Irregular Heartbeat 

WebMD: Could Chocolate Guard Against an Irregular Heartbeat?

May 22, 2017 : Nature Genetics

A team of researchers has identified 15 new genes associated with an increased risk for coronary artery disease (CAD), a type of heart disease that is a leading cause of death worldwide. The researchers found that many of these genes are linked to cells lining the blood vessels. This new discovery brings the total number of genes associated with CAD risk to 73. Their study, published in Nature Genetics, is partly funded by NHLBI.

Medical Xpress:  New heart disease risk genes point to flaws in blood vessel walls

Scope: Scientists make strides in hunt for genetic causes of heart disease

GenomeWeb: New Risk Loci for Coronary Artery Disease Shed Light on Mechanisms of Progression

ScienceDaily: New heart disease risk genes point to flaws in blood vessel walls

May 18, 2017 : The New England Journal of Medicine

Mast cells, a type of white blood cell, are present in the airways of severe asthmatics even in the face of aggressive treatment. In a new, proof-of-principle study published in the New England Journal of Medicine, NHLBI-funded researchers found that targeting the mast cells with imatinib, a drug used in cancer treatments, improved airway hyperresponsiveness, a measure of the sensitivity of the airway, and decreased the number of mast cells present in the airway.

STAT: Blockbuster cancer drug shows surprising promise in treating severe asthma

Pharmacy Times: Could This Cancer Drug Benefit Patients with Severe Asthma?

Drug Discovery and Development: Study Finds Imatinib Improves Symptoms for Patients with Severe Asthma

Medical Xpress: Proof-of principle study finds imatinib improves symptoms for patients with severe asthma

Washington University School of Medicine: Cancer drug may help patients with severe asthma

May 17, 2017 : Nature

Researchers are reporting in studies using mice that they have developed a practical, efficient method for reprogramming adult endothelial cells (cells that line the blood vessels) into hematopoietic stem cells, a type of stem cell that can produce all blood cell types.  The lab-grown stem cells could help expand the supply of stem cells used for treating leukemia and other blood disorders in people who need bone marrow transplants.  The study, published in Nature, is partly funded by NHLBI.

Scientific American:  Lab-Grown Blood Stem Cells Produced At Last

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