Researchers partly funded by NHLBI have identified 107 new genetic regions associated with high blood pressure, which could enable doctors to identify at-risk patients and better target treatment. As part of the study, published in the journal Nature Genetics, the researchers developed a genetic ‘risk score’ that, they say, if measured in early life might open the door to a personalized medicine approach to prevention of cardiovascular disease.
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Infants and children who suffer a cardiac arrest in the hospital do not benefit from body cooling, or therapeutic hypothermia, according to an NHLBI-funded study. The findings were published in the New England Journal of Medicine and indicated that health outcomes for children treated with body cooling, which lowers the temperature below normal range, were no better than for those whose temperature was kept within normal range. Read release.
It is not just the extra fat in the body, but where it is stored that increases the risks for diabetes, heart disease and stroke. NHLBI-funded researchers have identified seven new areas of the genome that influence the storage of fat. The study published in Nature Genetics might lead to insights for prevention and targeted therapies. Read the release.
The risk for heart disease and stroke is significantly greater for black men and women living in impoverished, usually urban neighborhoods, according to an NHLBI-funded study published in the American Journal of Public Health. The researchers analyzed data from the Jackson Heart Study and the 2000 U.S. Census, and found that every step down the scale used to measure socioeconomic status was associated with a 25 percent rise in heart disease risk.
Researchers are reporting development of a new method that could improve the safety and efficacy of bone marrow transplants used for treating advanced blood cancers. In the new study using mouse models of lymphoma (a type of blood cancer), the researchers genetically engineered immune cells (T cells) from a donor in a way that made the cells less likely to cause graft-versus-host disease (GVHD). GVHD is a potentially deadly complication in which donor white blood cells attack healthy tissues in the recipient. The study, published in Nature Medicine, was partly funded by NHLBI.
Most parents would be surprised to learn how much their exercise habits are followed by their young children. Literally followed. That was a key finding of an NHLBI-funded study published in the American Journal of Preventive Medicine. Researchers found a direct correlation between the physical activity of parents and their preschool-age children in underserved populations. Read the release.
Complications from asthma, including death, are more likely for African Americans. A group of NHLBI-funded researchers found that a unique type of inflammation of the airways might be partly to blame, as it makes black patients less responsive to asthma treatment. The findings, published in the Journal of Allergy and Clinical Immunology, are the result of one of the largest and most diverse U.S. clinical trials on race and asthma.
As we pledge to, this year definitely, follow through with the “lose-weight resolution,” the U.S. News & World Report annual diet rankings come not a minute too soon. And, the NHLBI-developed DASH Diet wins the top spot for the seventh consecutive year as the “best overall” diet.
Scientists have known for years that patients with psoriasis are at increased risk for developing heart disease. Now, researchers are reporting that they have identified a group of molecules that may help explain this link. In a pair of studies in mice, researchers showed how the inflammatory response to psoriasis can lead to altered levels of certain immune system molecules, increasing the risk of fatal blood clots. The studies could lead to novel treatments to lower the risk of heart disease in people with psoriasis, the researchers say. One of the studies, published in the Journal of Clinical Investigation Insight, was partly funded by NHLBI.
Go ahead, sleep in on a weekend; but don’t think you are making up for lost hours of sleep over the work week, says an NHLBI-funded study, published in the journal Brain, Behavior, and Immunity. The researchers, while noting that this was a small study, stress two key findings. First, sleeping in on weekends does not appear to restore the body’s stress responses down to normal levels. Second, the habit of deprivation during the week and “binging” on sleep on weekends is very hard to break the longer it continues, as people are less likely to realize they are sleepy and have more trouble doing everyday tasks.