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May 23, 2017 : JAMA Internal Medicine
No statin primary prevention benefit seen for seniors

A study partly funded by NHLBI showed that seniors aged 65 to 74 don’t benefit from taking statins as prevention against cardiovascular disease or mortality. The findings appear in the JAMA Internal Medicine. “No benefit was found when a statin was given for primary prevention to older adults. Treatment recommendations should be individualized for this population,” the article concludes.

Healio: Statins yielded no benefit for primary cardiovascular prevention in older adults 

Onmedica: Starting statins not beneficial in many older adults 

Medpage Today: Analysis: No Statin Primary Prevention Seen for Seniors 

May 23, 2017 : The New York Times
Why Chocolate May Be Good for the Heart

Great news for chocolate lovers: Researchers are reporting a link between eating the popular treat and a lowered risk for atrial fibrillation, a type of irregular heartbeat that can lead to stroke, heart failure, and other problems.  Their study, published in Heart (BMJ), was supported by NHLBI.

CBS News: Chocolate linked to lower risk for heart condition AFib 

Fox News: A new health benefit of chocolate: reduced risk of AFib?  

Reuters: Chocolate tied to decreased risk of irregular heart rhythm 

Forbes: Chocolate May Reduce Risk Of Developing Common Heart Arrhythmia 

Newsweek: Want a Healthy Heart? Eat Chocolate, New Study Says

Live Science:  Sweet Therapy: Chocolate May Help Prevent Irregular Heartbeat 

WebMD: Could Chocolate Guard Against an Irregular Heartbeat?

May 22, 2017 : Nature Genetics
Researchers identify 15 new genes associated with increased risk for heart disease

A team of researchers has identified 15 new genes associated with an increased risk for coronary artery disease (CAD), a type of heart disease that is a leading cause of death worldwide. The researchers found that many of these genes are linked to cells lining the blood vessels. This new discovery brings the total number of genes associated with CAD risk to 73. Their study, published in Nature Genetics, is partly funded by NHLBI.

Medical Xpress:  New heart disease risk genes point to flaws in blood vessel walls

Scope: Scientists make strides in hunt for genetic causes of heart disease

GenomeWeb: New Risk Loci for Coronary Artery Disease Shed Light on Mechanisms of Progression

ScienceDaily: New heart disease risk genes point to flaws in blood vessel walls

May 18, 2017 : The New England Journal of Medicine
Imatinib, a cancer drug, shows promise in treatment of severe asthma

Mast cells, a type of white blood cell, are present in the airways of severe asthmatics even in the face of aggressive treatment. In a new, proof-of-principle study published in the New England Journal of Medicine, NHLBI-funded researchers found that targeting the mast cells with imatinib, a drug used in cancer treatments, improved airway hyperresponsiveness, a measure of the sensitivity of the airway, and decreased the number of mast cells present in the airway.

STAT: Blockbuster cancer drug shows surprising promise in treating severe asthma

Pharmacy Times: Could This Cancer Drug Benefit Patients with Severe Asthma?

Drug Discovery and Development: Study Finds Imatinib Improves Symptoms for Patients with Severe Asthma

Medical Xpress: Proof-of principle study finds imatinib improves symptoms for patients with severe asthma

Washington University School of Medicine: Cancer drug may help patients with severe asthma

May 17, 2017 : Nature
Researchers develop practical method for converting blood vessel cells into stem cells for treating blood diseases

Researchers are reporting in studies using mice that they have developed a practical, efficient method for reprogramming adult endothelial cells (cells that line the blood vessels) into hematopoietic stem cells, a type of stem cell that can produce all blood cell types.  The lab-grown stem cells could help expand the supply of stem cells used for treating leukemia and other blood disorders in people who need bone marrow transplants.  The study, published in Nature, is partly funded by NHLBI.

Scientific American:  Lab-Grown Blood Stem Cells Produced At Last

May 16, 2017 : JAMA
Cardiovascular Mortality Differences—Place Matters

An editorial by NHLBI director, Gary Gibbons, M.D. and colleagues, published by JAMA discusses the findings of a study in the journal about the geographic variation in cardiovascular mortality in the United States. The findings “serve as a critical reminder to challenge clinicians, investigators, and public health leaders to imagine a future in which an individual’s risk of cardiovascular death is no longer determined by “the place” he or she was born or resides and no longer prevents pursuing a healthy and fulfilling life,” said the authors.

Reuters: U.S. heart disease deaths drop but wide variation by county remains

American Heart Association News: Heart disease, stroke death rates vary widely depending on where you live

HealthDay: Heart Health Might Be a Matter of Geography

Becker’s Hospital Review: Geography matters for heart disease deaths, study shows

May 16, 2017 : U.S. News & World Report
High-dose iron pills do not improve exercise capacity for certain type of heart failure

High-dose iron pills do not improve exercise capacity in people with a certain type of heart failure frequently marked by iron deficiency, researchers are reporting.  In a study that measured exercise capacity among 225 patients with heart failure with reduced left ventricular ejection fraction, the researchers found no significant difference between those who received iron pills and those who received placebo after 16 weeks of treatment. The study, published in JAMA, is partly funded by NHLBI.

Medical Xpress: High-dose iron pills do not improve exercise capacity for heart failure

May 10, 2017 : Medical Xpress
Study finds link between a stroke-causing brain disease, gut bacteria

Researchers are reporting that bacteria in the gut may contribute to the formation of cerebral cavernous malformations (CCMs), clusters of dilated, thin-walled blood vessels in the brain that can cause stroke and seizures.  The researchers suggest that altering the gut bacteria in people with CCMs may provide a promising treatment for this brain disease. Their study, which appeared in Nature, was partly funded by NHLBI.

May 3, 2017 : Nature
Study of blood vessel growth may open new pathway to therapies

A study partly funded by NHLBI details the development of blood vessels. The authors think that the finding, published in Nature(link is external), shows pathways for new treatments of cardiovascular diseases and cancer. 

Health Canal(link is external)

Technology.org(link is external)

YaleNews(link is external)

Medical Xpress

May 2, 2017 : Cell Metabolism
NIH discovery in mice could lead to new class of medications to fight mid-life obesity

Researchers led and partly funded by NHLBI have identified an enzyme that could help in the continuous battle against mid-life obesity and fitness loss. Reported in Cell Metabolism, the discovery in mice could upend current notions about why people gain weight as they age, and could one day lead to more effective weight-loss medications.   

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