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July 18, 2017 : JAMA

Moderate weight gain during adulthood is associated with a significantly increased risk of major chronic diseases—including diabetes and heart disease—as well as an increased risk of death, according to a new study involving more than 100,000 people.  The study emphasizes the importance of preventing weight gain during adulthood, the researchers say. Partly funded by NHLBI, the findings appear in the Journal of the American Medical Association (JAMA).

HealthDay: More evidence that midlife weight gain harms your health
Clinical Endocrinology News: Even a few middle age pounds are dangerous
MedPage Today: Adding pounds in adulthood ups major health risks
Medscape: Modest weight gain in young adulthood hikes chronic disease risk
Medical News Today: Weight gain in early adulthood linked to health risks later in life

July 11, 2017 : eLife

Researchers are reporting that galectin-3, a protein that promotes cancer cell growth and is used as a biomarker for heart failure, is linked to tumors associated with two rare genetic diseases.  They found that the protein is produced by tumor cells in tuberous sclerosis complex (TSC), a genetic disease that produces tumors in a variety of organs, and lymphangioleiomyomatosis (LAM), a lung disease that typically affects women. This biomarker could be useful for assessing the severity of these two diseases and for evaluating response to treatments, the researchers say. Their study, which was partly funded by NHLBI, appears in the journal eLife Study links heart failure biomarker to tumors observed in rare genetic diseases

Newswise: Heart Failure Biomarker Linked to Rare Genetic Tumor-Causing Diseases

July 6, 2017 : Nature

Moving genes about, as if a DJ were mixing music, could help cells respond to the changing conditions because a gene alters its activity when its location changes within a cell, according to an NHLBI-funded study published in the journal Nature.

Scicasts: Study Reveals Genes Are Constantly Rearranged By Cells Detailed study reveals genes are constantly rearranged by cells

Cambridge Network: Genetic DJ: Growing cells remix their genes

June 26, 2017 : Health Affairs

Researchers are reporting that crowded emergency rooms result in worse heart attack survival for black patients when compared to whites. The study examined a database of 91,000 patients in California who had experienced heart attacks between 2001 and 2011. The researchers found that when ambulances are diverted for extended periods lasting six to 12 hours—bypassing the nearest hospitals due to overcrowded emergency rooms—black patients were more likely to die within a year of their heart attack compared to their white counterparts. The study, which was partly funded by NHLBI, appeared in the journal Health Affairs.   

Reuters: Crowded U.S. emergency depts tied to worse heart attack survival for blacks

Medical Xpress: Team studies ambulance diversion by race, health care for released prisoners

San Francisco Examiner: UCSF study finds higher mortality rates for blacks near crowded hospitals than whites

June 21, 2017 : Time

Researchers funded by NHLBI found that a gene mutation called clonal hematopoiesis of indeterminate potential (CHIP) showed a higher rate of heart disease, according to a paper published in The New England Journal of Medicine. People do not inherit the CHIP mutations, instead, they accumulate over time from the exposure to things that damage DNA.

TIME: The Unexpected Way Genes Can Double Heart Disease Risk

Medscape: Changes in Peripheral Blood Cells Linked to Increased CHD

Healio: Clonal hematopoiesis of indeterminate potential increases CHD risk

MedpageToday: CHIP May Connect Age, Atherosclerosis, and CHD

GenomeWeb: Cardiovascular Disease Risk Is Increased by Aging-Related Mutations in Blood Cells

DoctorsLounge: Clonal Hematopoiesis Linked to Coronary Heart Disease

The Stem Cellar: Cancer-causing mutations in blood stem cells may also link to heart disease

The New England Journal of Medicine: Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

June 12, 2017 : JAMA Internal Medicine

Men and women with the lowest education level had higher lifetime risks of cardiovascular disease (CVD) than those with the highest education level, according to an NHLBI-funded study published by JAMA Internal Medicine. The findings reinforce that one of the most important socioeconomic factors contributing to CVD is educational inequality. Heart disease: Going to university 'could slash your risk if you are a woman' Patient's Education Level May Be Key to Heart Risk

Science Daily: Is educational attainment associated with lifetime risk of cardiovascular disease?

Live Science: How Your Education Level May Be Linked to Your Risk of Heart Disease

Healio: Educational attainment inversely associated with lifetime CVD risk

El Universal: Tu nivel educativo marca tu riesgo cardiovascular Las personas con menor nivel educativo tienen mayor riesgo de enfermedad cardiovascular

Daily Mail: Going to university HALVES your risk of heart disease, 30-year study shows

May 31, 2017 : JAMA Cardiology

Researchers are reporting that treating skin inflammation in people with psoriasis may have beneficial effects on underlying inflammation of the blood vessels and help reduce the risk of atherosclerosis and heart disease in these individuals.  The study, published in JAMA Cardiology, is funded by NHLBI.

MedPage Today: Can Psoriasis Tx Diminish Atherosclerosis?

May 31, 2017 : JAMA Cardiology

Reducing systolic blood pressure to levels below currently recommended targets may significantly reduce the risk of cardiovascular disease and save lives, according to a new study published in JAMA Cardiology. The study is based on a systematic review and analysis of 42 clinical trials involving 144,220 people.  It is partly funded by NHLBI.  

MedPage Today: New Review Supports Aggressive BP Targets

Medical Xpress: Findings suggest reducing target SBP to below recommended levels could significantly reduce risk

Physician’s Briefing: Reducing SBP Targets Below Current Guidelines Cuts Risk

News Medical: Reducing target systolic blood pressure lowers risk of cardiovascular disease and mortality

Science Daily: Lower targets for systolic blood pressure suggested by study

May 24, 2017 : The Atlantic

Researchers partly funded by NHLBI revealed that the Zika virus showed up in the Americas several months, perhaps even years, before anyone realized it. In the study published in the journal Nature the researchers mapped 54 complete or partial genomes of DNA of the virus in order to track its spread through the continent.

Los Angeles Times: What the DNA of the Zika virus tells scientists about its rapid spread

Wired: Virus Hunters Draw a Map of Zika’s Spread With DNA

The San Diego Union-Tribune: Zika struck Florida up to 40 times before detection

TheScientist: Tracing Zika’s Spread Through Genetics

ScienceNews: The Zika epidemic began long before anyone noticed

May 24, 2017 : The New York Times

Some people are natural knockouts, that is, they are born missing one of more genes. This presents a great opportunity to study what a specific gene does. A team of researchers partly funded by NHLBI has described more than 1,800 so-called "human knockouts" in a major study published in Nature. Another NHLBI-funded study in the  recent study in the Journal of the American College of Cardiology showed how these genetic mutations validate a new strategy for reducing cholesterol.

Science Now: Human ‘knockouts’ may reveal why some drugs fail

EurekAlert: Genetics of first-cousin marriage families show how some are protected from heart disease

ScienceNews: Gene knockouts in people provide drug safety, effectiveness clues How 1,800 Pakistanis are helping Penn scientists fight disease

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