NHLBI-funded researchers at Brigham and Women's Hospital found that a genetic risk score identified individuals at increased risk for cardiovascular death or a heart attack, both in individuals with and without known coronary disease, with individuals in the highest genetic risk score group having more than a 70 percent increase in the risk of cardiovascular death or a heart attack compared to the lowest risk group
NHLBI In The News
NHLBI-funded researchers from The University of Texas Health Science Center and other locations found evidence to support the use of a battlefield blood transfusion protocol for severely injured trauma patients. The study detailing these findings appears in the Journal of the American Medical Association.
DNA methylation levels change with age. Recent studies have identified biomarkers of chronological age based on DNA methylation levels. It is not yet known whether DNA methylation age captures aspects of biological age. The paper reports that DNA methylation-derived measures of accelerated ageing are heritable traits that predict mortality independently of health status, lifestyle factors, and known genetic factors. Researchers from the NHLBI's Framingham Heart Study were among the authors of this paper.
NHLBI-funded work from the Broad Institute and other research centers has identified rare genetic mutations that increase a person's risk of having a heart attack early in life.
A new study in the Journal of the American Heart Association reports a significant association between living near a major roadway and the risk of high blood pressure. The Brown University-led analysis used data from NHLBI's Women's Health Initiative and assessed 5,400 post-menopausal women in the San Diego metropolitan area. Researchers found that women who lived within 100 meters of a highway or major arterial road had a 22-percent greater risk of hypertension than women who lived at least 1,000 meters away. In a range of intermediate distances, hypertension risk rose with proximity to the roadways.
Genes may interact with stress to trigger heart disease in some people, a new study suggests. The genetic risk occurs in about 13 percent of people, but only in those who are white. The finding could help these people reduce their heart disease risk through simple measures such as exercise, a healthy diet and stress management, the Duke University researchers said. This research was funded in part by the NHLBI.
Each day, more than 100,000 people suffer from a chronic, genetic blood disease that causes debilitating pain. This episode of CTSI Discovery Radio discusses new ways people living with Sickle Cell Disease are finding some relief right through new clinical trials, a medical home for Sickle Cell patients, and new guidelines to help lower the risk of the disease causing a crisis in patients it affects. This segment features NHLBI's Dr. Keith Hoots.
Scientists from UCLA's Jonsson Comprehensive Cancer Center (JCCC) have shown for the first time how a unique protein found in human bone marrow can drive stem cells to repair our blood system after an injury. These groundbreaking findings provide a roadmap to make existing radiation and chemotherapy treatments more effective for patients with cancer and other blood-related diseases. This research was funded in part by the NHLBI.
Platelets, the tiny cell fragments whose job it is to stop bleeding, are very simple. They don’t have a cell nucleus. But they can "feel" the physical environment around them, researchers at Emory and Georgia Tech have discovered.
Pretty much any animal medical researchers test is male. So too are the tissues they use to conduct tests. Despite the loads of research demonstrating important biological differences between how men and women react to various drugs or diseases, the default study subject is male.
That trend’s about to change, as the world’s largest medical funding agency — the US National Institutes of Health — announced today that it would grant a total of $10 million to 80 researchers who will study the effects of gender in their work.