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August 8, 2017 : The Huffington Post

Middle aged people with risk factors for heart attacks and stroke, including diabetes, high blood pressure and smoking, have a greater chance of suffering from dementia later in life, according to a study, partly funded by NHLBI, published in JAMA Neurology.

The Huffington Post: Heart Disease Risk In Middle Age Tied To Dementia Later

WebMD: 'Heart Harm' In Middle Age Can Lead To Dementia

Drug Discovery and Development: Midlife Heart Health Linked to Risk of Dementia

Medscape: Prehypertension in Midlife Ups Later Dementia Risk

Medpage Today: Midlife Vascular Risk Factors Linked to Dementia

Business Standard: Diabetes, high BP in midlife may up dementia risk later

More coverage

August 7, 2017 : Nature Genetics

Some people are better than others at recovering from a wounded heart, and not everyone ends up with permanent muscle loss after a heart attack, according to study published in Nature Genetics, and partly funded by NHLBI.

Business Standard: Some people better at recovering from wounded heart

The New Indian Express: Not all of us is prone to muscle loss after heart attack, here's why

Fight Aging!: Identification of a Potential Cause in Variability of Heart Regeneration

Scicasts: Stem Cell Discovery Refreshes the Heart

The Stem Cellar: How mice and zebrafish are unlocking clues to repairing damaged hearts

July 26, 2017 : Nature

Scientists are reporting that stem cells in the brain may control aging.  Their study, conducted in mice, could lead to new strategies to prevent age-related diseases and extend lifespan.  Partly funded by NHLBI, the study appears in Nature
 
HealthDayIn Mice, Brain Cells Discovered That Might Control Aging
Science MagazineThe breakdown of this brain region may accelerate aging
Scientific AmericanBrain's Stem Cells Slow Ageing in Mice
The ScientistStem Cells in the Hypothalamus Slow Aging in Mice
STATA tiny part of the brain appears to orchestrate the whole body’s aging
Science DailyBrain cells found to control aging
Medical News TodayCould stem cells reverse the aging process?
Genetic Engineering & Biotechnology News:  Only as Old as the Brain’s Stem Cells Feel 

July 18, 2017 : JAMA

Moderate weight gain during adulthood is associated with a significantly increased risk of major chronic diseases—including diabetes and heart disease—as well as an increased risk of death, according to a new study involving more than 100,000 people.  The study emphasizes the importance of preventing weight gain during adulthood, the researchers say. Partly funded by NHLBI, the findings appear in the Journal of the American Medical Association (JAMA).

HealthDay: More evidence that midlife weight gain harms your health
Clinical Endocrinology News: Even a few middle age pounds are dangerous
MedPage Today: Adding pounds in adulthood ups major health risks
Medscape: Modest weight gain in young adulthood hikes chronic disease risk
Medical News Today: Weight gain in early adulthood linked to health risks later in life

July 17, 2017 : JAMA Internal Medicine

Researchers have developed an online calculator that can help young people predict their risk of developing heart disease in middle age in an effort to reduce their chances of developing a heart attack or stroke. Called the Healthy Heart Tool, the survey examines nine lifestyle factors that can influence the risk of heart disease, including smoking, weight, exercise, and food consumption.  It worked “moderately well” at predicting heart disease risk in a group of nearly 5,000 adults followed more than two decades, they say. The study, which appears in JAMA Internal Medicine, is partly funded by NHLBI.

Reuters: Online tool predicts heart risk in young adults

Healio: Healthy Heart Score performs ‘moderately well’ estimating risk for early CVD events

2 Minute Medicine: Healthy Heart Score performed moderately well in assessing cardiovascular disease risk in young adults

July 11, 2017 : eLife

Researchers are reporting that galectin-3, a protein that promotes cancer cell growth and is used as a biomarker for heart failure, is linked to tumors associated with two rare genetic diseases.  They found that the protein is produced by tumor cells in tuberous sclerosis complex (TSC), a genetic disease that produces tumors in a variety of organs, and lymphangioleiomyomatosis (LAM), a lung disease that typically affects women. This biomarker could be useful for assessing the severity of these two diseases and for evaluating response to treatments, the researchers say. Their study, which was partly funded by NHLBI, appears in the journal eLife

NewsMedical.net: Study links heart failure biomarker to tumors observed in rare genetic diseases

Newswise: Heart Failure Biomarker Linked to Rare Genetic Tumor-Causing Diseases

July 10, 2017 : Circulation

Black adults are more likely than whites to die following a first-time heart attack, according to a new study.  In a review of major heart studies involving more than 28,000 people, researchers found that black men between the ages of 45 and 64 were twice as likely to die of a first-time heart attack than white men.  For black women, the risk of a first-time fatal heart attack was also greater than white women in the same age range, the researchers found. The study, funded in part by NHLBI, appears in the journal Circulation.

UPI: Study: Fatal first-time heart attacks more common in black adults

WebMD: Fatal First Heart Attacks More Common in Blacks

U.S. News & World Report: Fatal First-Time Heart Attacks More Common in Blacks: Study

Cardiovascular Business: Study suggests first cardiac events more fatal for black patients

Science Daily: Blacks suffer higher rates of fatal first-time heart attacks than whites

July 6, 2017 : Nature

Moving genes about, as if a DJ were mixing music, could help cells respond to the changing conditions because a gene alters its activity when its location changes within a cell, according to an NHLBI-funded study published in the journal Nature.

Scicasts: Study Reveals Genes Are Constantly Rearranged By Cells

Phys.org: Detailed study reveals genes are constantly rearranged by cells

Cambridge Network: Genetic DJ: Growing cells remix their genes

June 26, 2017 : Health Affairs

Researchers are reporting that crowded emergency rooms result in worse heart attack survival for black patients when compared to whites. The study examined a database of 91,000 patients in California who had experienced heart attacks between 2001 and 2011. The researchers found that when ambulances are diverted for extended periods lasting six to 12 hours—bypassing the nearest hospitals due to overcrowded emergency rooms—black patients were more likely to die within a year of their heart attack compared to their white counterparts. The study, which was partly funded by NHLBI, appeared in the journal Health Affairs.   

Reuters: Crowded U.S. emergency depts tied to worse heart attack survival for blacks

Medical Xpress: Team studies ambulance diversion by race, health care for released prisoners

San Francisco Examiner: UCSF study finds higher mortality rates for blacks near crowded hospitals than whites

June 21, 2017 : Time

Researchers funded by NHLBI found that a gene mutation called clonal hematopoiesis of indeterminate potential (CHIP) showed a higher rate of heart disease, according to a paper published in The New England Journal of Medicine. People do not inherit the CHIP mutations, instead, they accumulate over time from the exposure to things that damage DNA.

TIME: The Unexpected Way Genes Can Double Heart Disease Risk

Medscape: Changes in Peripheral Blood Cells Linked to Increased CHD

Healio: Clonal hematopoiesis of indeterminate potential increases CHD risk

MedpageToday: CHIP May Connect Age, Atherosclerosis, and CHD

GenomeWeb: Cardiovascular Disease Risk Is Increased by Aging-Related Mutations in Blood Cells

DoctorsLounge: Clonal Hematopoiesis Linked to Coronary Heart Disease

The Stem Cellar: Cancer-causing mutations in blood stem cells may also link to heart disease

The New England Journal of Medicine: Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

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