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Sickle Cell in Focus 2017
26-27 October 2017
Jamaica Pegasus Hotel
Kingston, Jamaica
DAY ONE: THURSDAY 26th October 2017
8:00am Registration
9:00am Welcome and Introduction
Speaker: TBD
SESSION ONE: Evolution of SCD- Where are we now?
9:05am Worldwide impact of SCD
Graham Serjeant
Sickle Cell Trust, Kingston, Jamaica
9:35am Newborn screening and early childhood care, integration into public health rather than academic settings
Jennifer Knight-Madden
University of the West Indies, Kingston, Jamaica
10:05am Point-of-care testing for SCD
Speaker: Carolyn Hoppe
Children's Hospital & Research Center Oakland, Oakland, CA
10:35am BREAK
SESSION TWO: Clinical Management (I) – Challenges in Adult care
10:50am Clinical manifestations and complications in adult.
Jo Howard
Guy's and St Thomas' Hospitals NHS Foundation Trust, London, UK
11:20pm Pulmonary/cardiac complications
Elizabeth Klings
Boston University School of Medicine, Boston, MA, USA
11:50pm Neurological complications
James Casella
Johns Hopkins University School of Medicine, Baltimore, MD, USA
12:20pm LUNCH
SESSION THREE: Clinical Management (II)- Challenges in Adult Care
1:20pm Challenges in pain management
Patrick Carroll
Johns Hopkins University School of Medicine, Baltimore, MD, USA
1:50pm Hydroxyurea- Expanding hydroxyurea therapy
Jane Hankins
St. Jude Children's Research Hospital, Memphis, TN, USA
2:20pm Blood transfusion- when and how to transfuse
Ross Fasano
Emory University School of Medicine, Atlanta, GA, USA
2:50pm How I manage renal complications
Monika Asnani
University of the West Indies, Kingston, Jamaica
3:20pm BREAK
SESSION FOUR: New Disease-Modifying Drugs
3:35am Targeting HbS polymerization
William Eaton
National Institutes of Health, Bethesda, MD, USA
DEBATE 1: Advancing clinical care to developing countries - Research should be home-grown rather than imported
4:05pm Pro: Tom Williams
KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya
4:25pm Con: Isaac Odame
The Hospital for Sick Children, Toronto, ON, Canada
4:45pm Debate
5:05pm DAY ONE CLOSE
Day Two: Friday, 27th October 2017
8:00am Registration
8:55am Welcome and Introduction
Speaker: TBD
SESSION FOUR (Cont.): New Disease-Modifying Drugs
9:00am New Insights in pathophysiology of SCD and development of therapies targeting pathways downstream
of sickling
Marvin Reid
University of the West Indies, Kingston, Jamaica
9:30am Pharmacological induction of HbF
Yogen Saunthararajah
Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA
10:00am BREAK
SESSION FIVE: Curative Therapies
10:15am Genetic approaches for increasing HbF- gene addition, shRNA, chromosome looping
Mitch Weiss
St. Jude Children's Research Hospital, Memphis, TN, USA
10:45pm Genetic corrections- genome editing, lentiviral
Giuliana Ferrari
Vita-Salute San Raffaele University, Milan, Italy
11:15pm Allogeneic transplants- matched and haplo-identical
Courtney Fitzhugh
National Institutes of Health, Bethesda, MD, USA
11:45pm LUNCH
SESSION SIX: New Approaches to studying sickle erythrocyte rheology
12:45pm Microfluidic characterization of SCD biorheology
Wilbur Lam
Emory University, Atlanta, GA, USA
1:15pm Biorheology of RBCs through the spleen- towards an understanding of splenic pathology
Pierre Buffet
Université Paris Descartes, Paris, France
1:45pm Point-of care monitoring of RBS adhesion as marker of disease severity and monitoring
therapy
Umut Gurkan
Case Western Reserve University, Cleveland, OH, USA
SESSION SEVEN: A better understanding towards sickle cell trait
2:15pm Sickle trait: Is it completely harmless? - An overview of evidence on exertion related events
Francis O’Connor
Uniformed Services University of the Health Sciences, Bethesda, MD, USA
2:45pm HbAS with sickle complications- a diagnostic challenge
Swee Lay Thein
National Institutes of Health, Bethesda, MD, USA
3:15pm Sickle Cell Trait- impact on coagulation and kidneys
Rakhi Prakash Naik
Johns Hopkins University School of Medicine, Baltimore, MD, USA
3:45pm BREAK
DEBATE 2: One clot in a patient with SCD justifies life-long anti- coagulation
4:00pm Pro: Arun Shet
National Institutes of Health, Bethesda, MD, USA
4:20pm Con: Theodore Wun
VA Northern California Health Care System/ UC Davis Comprehensive Cancer Center, Sacramento, CA, USA
4:40pm Debate
5:00pm CLOSE OF CONFERENCE