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Medical lab test
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Research Feature
“Look at that! Life!” said Deidra Flowers-Williams , a sickle cell disease patient, as she held up a tube with stem cells donated by her sister, Tanisha Flowers. It was just minutes before doctors at the NIH Clinical Center would use the cells – extracted from her sister’s bone marrow – for a transplant they hoped would cure the devastating blood...
Technician operates Gazelle platform, a portable lab-on-a-chip device that can identify sickle cell disease from a blood droplet. Photo source: Hemex Health
Credit: Hemex Health
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Research Feature
About 20 years ago, researchers excitedly announced the coming of so-called lab-on-chip devices that could revolutionize medicine. At the time, people marveled at the possibilities: The devices would take the capabilities of a large biochemistry lab and shrink them to a platform the size of a cell phone or smaller. With help from a portable scanner...
A physician talks to a young patient in a medical exam room.
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Research Feature
At St. Louis Children’s Hospital in Missouri, a 12-year-old boy waiting in an exam room held a tablet as he scrolled through a trivia game about sickle cell disease (SCD) – an inherited blood disorder that had brought him to the hospital for a regular visit. As he played the game, he won a badge each time he answered a question right. But happily...
 Sickle cell anemia disease (SCD) blood cells 3D illustration
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News Release
Finding could lead to new ways to reduce complications from painful red blood cell disorder Researchers have discovered that DNA from the mitochondria - the cell’s “powerhouses” - acts as a danger signal in the body and triggers inflammation in people with sickle cell disease. A better understanding of mitochondrial DNA, long known to circulate in...
This photo shows a technician use a scanner device to take temperature of man wearing mask in assessment for COVID-19.
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Research Feature
The coronavirus pandemic has caused tragedy and turmoil for millions of people around the world, but it has been particularly unkind to one group whose health journey is often overlooked: Those with sickle cell disease. A growing number of studies now suggest that people with this painful genetic blood disorder who also are infected with SARS-CoV-2...
An example of what the InCharge Health app would look like on a smartphone.
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Research Feature
A new smartphone app could be a boon for adolescents, young adults When the Food and Drug Administration (FDA) approved the drug hydroxyurea to help reduce the excruciating pain suffered by people with sickle cell disease, the health care community was hopeful. The year was 1998, and the prospect of a drug that could offer significant relief from...
Close-up hand's doctor or nurses are vaccination to patient using the syringe injected upper arm for treated
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Research Feature
Multi-institute NIH study suggests that the HPV vaccine could protect women against new HPV infections after stem cell transplantation The human papillomavirus (HPV) vaccine provides a safe, robust immune response against HPV in reproductive-aged women who have had a stem cell transplant. The results from the small study published in the Journal of...
image of bags of blood.
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News Release
Fresh red blood cell transfusions do not help critically ill children more than older cells NIH-funded finding may alter policies at hospitals where fresh red cells are preferentially used Researchers have found that transfusions using fresh red blood cells—cells that have spent seven days or less in storage—are no more beneficial than older red...
About 1 in every 16,300 Hispanic babies is born with sickle cell disease
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Research Feature
En el 2000, Mercy Mendoza, a los 3 años, languidecía con una enfermedad misteriosa. Su abuela, desesperanzada, compró un sitio donde enterrarla en el pueblito de Honduras donde vivían. La hinchazón, el dolor y la inmovilidad estaban erosionando rápidamente su salud. Finalmente, un médico que había estudiado en los Estados Unidos reconoció su...
About 1 in every 16,300 Hispanic babies is born with sickle cell disease.
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Research Feature
In 2000, a mysterious disease was making 3-year-old Mercy Mendoza so ill that her grandmother bought a burial plot for her in the little town in Honduras where they lived. Swelling, pain, and immobility were fast eroding her health. Finally, a doctor who had been trained in the United States recognized her condition: It was sickle cell disease, an...