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Sickle Cell Disease
Sickle cell anemia disease (SCD) blood cells 3D illustration
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News Release
NIH scientists discover how DNA fragments can trigger inflammation in sickle cell disease
Finding could lead to new ways to reduce complications from painful red blood cell disorder Researchers have discovered that DNA from the mitochondria - the cell’s “powerhouses” - acts as a danger signal in the body and triggers inflammation in people with sickle cell disease. A better understanding of mitochondrial DNA, long known to circulate in...
This photo shows a technician use a scanner device to take temperature of man wearing mask in assessment for COVID-19.
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Research Feature
COVID-19 Posing Grim Challenge for Sickle Cell Disease Patients
The coronavirus pandemic has caused tragedy and turmoil for millions of people around the world, but it has been particularly unkind to one group whose health journey is often overlooked: Those with sickle cell disease. A growing number of studies now suggest that people with this painful genetic blood disorder who also are infected with SARS-CoV-2...
An example of what the InCharge Health app would look like on a smartphone.
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Research Feature
Rx Reminder: Helping People with Sickle Cell Disease Take Their Meds
A new smartphone app could be a boon for adolescents, young adults When the Food and Drug Administration (FDA) approved the drug hydroxyurea to help reduce the excruciating pain suffered by people with sickle cell disease, the health care community was hopeful. The year was 1998, and the prospect of a drug that could offer significant relief from...
Close-up hand's doctor or nurses are vaccination to patient using the syringe injected upper arm for treated
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Research Feature
HPV vaccine safely evokes immune response to HPV in women who have had a stem cell transplant
Multi-institute NIH study suggests that the HPV vaccine could protect women against new HPV infections after stem cell transplantation The human papillomavirus (HPV) vaccine provides a safe, robust immune response against HPV in reproductive-aged women who have had a stem cell transplant. The results from the small study published in the Journal of...
image of bags of blood.
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News Release
Blood transfusions in critically-ill children: fresh vs older red blood cells
Fresh red blood cell transfusions do not help critically ill children more than older cells NIH-funded finding may alter policies at hospitals where fresh red cells are preferentially used Researchers have found that transfusions using fresh red blood cells—cells that have spent seven days or less in storage—are no more beneficial than older red...
About 1 in every 16,300 Hispanic babies is born with sickle cell disease.
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Research Feature
Sickle Cell: One gene, many faces, and a quest for a cure
In 2000, a mysterious disease was making 3-year-old Mercy Mendoza so ill that her grandmother bought a burial plot for her in the little town in Honduras where they lived. Swelling, pain, and immobility were fast eroding her health. Finally, a doctor who had been trained in the United States recognized her condition: It was sickle cell disease, an...