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Congenital heart defects have long posed great risks for the 2.5 million Americans who currently live with them. Now this most common of birth defects has become the focus of an innovative research model that could mean a brighter, healthier future for many children born with this often life-threatening condition. The model, which already has been...
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News Release
Scientists have confirmed the role of a set of gene mutations in the development of congenital heart disease and simultaneously discovered a link between them and some neurodevelopmental abnormalities in children. These abnormalities include cognitive, motor, social, and language impairments. “The risk of developing neurodevelopmental disabilities...
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Research Feature
The National Heart, Lung, and Blood Institute (NHLBI)-supported Pediatric Cardiac Genomics Consortium recently released its first dataset into the NIH's database of Genotypes and Phenotypes (dbGaP) , enabling any researcher to analyze the genes of children with congenital heart diseases on a scale that has never before been possible. This genomic...
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WHAT: Findings from the first large-scale sequencing analysis of congenital heart disease bring us closer to understanding this most common type of birth defect. The analysis found that spontaneous, or de novo, mutations affect a specific biological pathway that is critical to aspects of human development, including the brain and heart. Congenital...
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News Release
A new state-of-the-art facility dedicated to pediatric cardiac imaging and intervention, co-established by the National Institutes of Health and Children’s National Medical Center, was opened with a special dedication ceremony today. The new facility, located at Children’s National in Washington, D.C., is the culmination of a long collaboration...
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Research Feature
Nine studies focus on heart, lung, and blood diseases The National Institutes of Health has funded nine new studies that will develop induced pluripotent stem cells , or iPS cells, from patients with genetic variations that have been associated with coronary artery disease, pulmonary hypertension, clotting disorders, diabetes, and other conditions....
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Research Feature
The heart is the first organ to form and begin working in humans. More than two decades of research have told us a lot about normal heart development. New diagnostic tools such as fetal echocardiography now allow doctors to find heart defects during pregnancy. In 1950, a child born with a congenital heart defect had only a 20 percent chance of...