Through a study published in Science, researchers describe a process where immune cells in mice may be able to sniff out plaque accumulating in the arteries. They believe that following these olfactory signals, these immune cells facilitate “cross-talk” with other cells. This type of inflammatory communication provides new insight into factors that contribute to atherosclerosis and adds to a growing field of “inflammasome” research.
Similar to “complosome” research led by NHLBI’s Laboratory for Complement and Inflammation Research, advancements in understanding how immune cells sense and respond to the early formation of atherosclerosis may help guide new ways to treat and prevent cardiovascular disease.
The study was partially supported by NHLBI and the National Institute of Diabetes and Digestive and Kidney Diseases.