Researchers examined variants in protein-coding regions of the genome in 47,532 East Asian individuals to identify 12 novel loci associated with blood lipid levels—risk factors for cardiovascular disease, fatty liver disease, age-related macular degeneration, and type 2 diabetes. The large-scale study has the potential to pinpoint the causes of various cardiovascular and metabolic disorders, thereby promoting translation of the findings of genetic studies into new therapies. The study, published in Nature Genetics, was partly funded by NHLBI.