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Agenda

Working Group
on
“Current and Future Directions in
Stem Cell Transplantation for Hemoglobinopathies”

August 10, 2000
8:15 a.m. - 4:00 p.m.

6701 Rockledge Drive, Room 9100-9104
Bethesda, Maryland 20892

 

8:15 - 8:30 a.m. Opening comments
Director, Division of Blood Diseases and Resources, NHLBI
Dr. Barbara Alving
Dr. Helena Mishoe, NHLBI

(Chair)
Dr. John DiPersio
Washington University School of Medicine

8:30 - 9:00
Dr. Mark Walters, Children’s Hospital of Oakland
Bone Marrow Transplantation for Sickle Cell Disease: Results of a Multi-Center Investigation

9:00 - 9:30
Dr. David Rizzieri, Duke University Medical Center
Chimerism Mediated Immunotherapy for Hemoglobinopathies

9:30 - 10:00
Dr. Suzanne Ildstad, University of Louisville
Mixed Chimerism to Treat Sickle Cell Disease in MHC-Disparate Recipients

10:00 - 10:30  Break

10:30 - 11:00
Dr. John Barrett,  National Heart, Lung, and Blood Institute
Non-myeloablative Transplants - Efficacy and Side Effects
Dr. John Tisdale, National Institute of Diabetes and Digestive and Kidney Diseases, NIH

11:00 -11:30
Dr. John Wagner, University of Minnesota
Transplantation of Children and Adults with Hemoglobinopathies

11:30 - Noon
Dr. Nancy Geller, National Heart, lung, and Blood Institute
Potential Novel Trial Designs for Stem Cell Transplantation

Noon - 12:30 P.M.
Dr. David Kodish, Rainbow Babies & Children’s Hospital
Ethical Issues in Stem Cell Transplantation
for Hemoglobinopathies

12:30 - 2:00   LUNCH (working lunch in small groups)
 

Toward Best Practices/Discussion Topics (Full Working Group)

2:00 - 3:30

 •  Patient Selection Criteria
    Dr. Kwaku Ohene-Frempong, Children’s Hospital of Philadelphia
    Dr. Lennette Benjamin, Albert Einstein College of Medicine
    Dr. Orah Platt , Children’s Hospital Medical Center

 •  Timing of Transplants
    Dr. Blanche Alter, Johns Hopkins School of Public Health Service
    Dr. Jeanne Smith, Columbia University
    Dr. Griffin Rodgers, National Institute of Diabetes and Digestive and Kidney Diseases

 • Preparative Regimens
    Dr. Barrett, National Heart, Lung, and Blood Institute
    Dr. Rizzieri, Duke University Medical Center

 • Transplant Associated Risks
    Dr. Suzanne Ildstad, University of Louisville
    Dr. Mark Walters, Children’s Hospital of Oakland

 •  Alternative Stem Cell Sources
    Dr. John Wagner, University of Minnesota
    Dr. John DiPersio, Washington University School of Medicine
    Dr. John Tisdale, National Institute of Diabetes and Digestive and  Kidney Diseases

 •  Patient/Parent Perspectives
    Dr. Alan Cohen, Children’s Hospital of Philadelphia
    Dr. David Kodish, Rainbow Babies & Children’s Hospital
    (Parent and/or Patient)

3:30 - 4:00
Open Discussion/Summation
Dr. DiPersio, Washington University School of Medicine

4:00    Adjournment

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