Sickle Cell Disease
0
Sickle Cell Disease

Sickle Cell Disease Causes and Risk Factors

Share

Sickle cell disease is a genetic disorder caused by mutations in the beta globin genes that leads to faulty hemoglobin protein, called hemoglobin S. Hemoglobin S changes flexible red blood cells into rigid, sickle-shaped cells. These sickle cells can block blood flow, and result in pain and organ damage. Medical Animation Copyright © 2022 Nucleus Medical Media, All rights reserved.

Sickle cell disease is inherited, meaning that it runs in families. People who have sickle cell disease inherit two abnormal hemoglobingenes, called hemoglobin S, one from each parent.

A person has sickle cell disease trait when the hemoglobin S gene is inherited from only one parent, and a normal hemoglobin gene — hemoglobin A — is inherited from the other. People who have sickle cell trait are generally healthy.

If you have sickle cell trait, you are a carrier of the hemoglobin S gene, so they can pass it on when they have a child. If the child’s other parent also has sickle cell trait or another abnormal hemoglobin gene, such as beta-thalassemia, hemoglobin C, hemoglobin D, or hemoglobin E, that child has a chance of having sickle cell disease. ​

Inheritance pattern for sickle cell disease

Inheritance pattern for sickle cell disease. 

In the image above, each parent has one normal hemoglobin A gene and one hemoglobin S gene, which means each of their children has:

  • A 25% chance of inheriting two normal hemoglobin A genes. In this case, the child does not have sickle cell trait or disease.
  • A 50% chance of inheriting one normal hemoglobin A gene and one hemoglobin S gene. This child has sickle cell trait.
  • A 25% chance of inheriting two hemoglobin S genes. This child has sickle cell disease.

It is important to keep in mind that each time this couple has a child, the chances of that child having sickle cell disease remain the same. In other words, if the firstborn child has sickle cell disease, there is still a 25% chance that the second child will also have the disease. Both boys and girls can inherit sickle cell trait, sickle cell disease, or normal hemoglobin.

If a person wants to know whether he or she carries a sickle hemoglobin gene, a doctor can order a blood test to find out.

What is a “sickled cell”?

Red blood cells with normal hemoglobin are disc-shaped and flexible so that they can move easily through large and small blood vessels to deliver oxygen throughout the body.

Sickled hemoglobin is not like normal hemoglobin. Sickle-shaped red blood cells are not flexible and can stick to vessel walls, causing a blockage that slows or stops the flow of blood. The abnormal hemoglobin can cause rigid strands to form within the red blood cell. These rigid strands can change the shape of the cell, causing the sickled red blood cell that gives the disease its name.

The sickle-shaped cells cannot deliver oxygen to the rest of the body. This can cause attacks of sudden severe pain, called pain crises. These pain attacks can occur without warning, and a person who has them often needs to go to the hospital for effective treatment.

Because sickle cells cannot change shape easily, they also tend to burst apart. Normal red blood cells live about 90 to 120 days, but sickle cells last only 10 to 20 days. The body is always making new red blood cells to replace the old cells. However, in sickle cell disease, the body may have trouble keeping up with how fast the cells are being destroyed. Because of this, the number of red blood cells is usually lower than normal. This condition, called anemia, can cause a person to have less energy.

Normal red cells and sickle red cells.
Normal red cells and sickle red cells. Figure A shows normal red blood cells flowing freely in a blood vessel. The inset image shows a cross-section of a normal red blood cell with normal hemoglobin. Figure B shows abnormal, sickled red blood cells blocking blood flow in a blood vessel. The inset image shows a cross-section of a sickle cell with abnormal (sickle) hemoglobin forming abnormal stiff rods.

What are the risk factors?

In the United States, most people who have sickle cell disease are of African ancestry or identify themselves as Black.

  • About 1 in 13 Black or African American babies is born with sickle cell trait.
  • About 1 in every 365 Black or African American babies is born with sickle cell disease.

There are also many people who have sickle cell disease who come from Hispanic, southern European, Middle Eastern, or Asian Indian backgrounds.

About 100,000 Americans have sickle cell disease.

What should you do if you are at risk?

People who do not know whether they carry an abnormal hemoglobin gene can ask their doctor to have their blood tested.

Couples who are planning to have children and know that they are at risk of having a child with sickle cell disease may want to meet with a genetic counselor. A genetic counselor can answer questions about the risk and explain the choices that are available.

Last updated on