Lymphopenia Symptoms

People who have lymphopenia may have no symptoms at all. If you get colds or pneumonia often or a more unusual infection, your healthcare provider may suspect that you have lymphopenia.

A low lymphocyte count alone may not cause any symptoms. Lymphopenia usually is found during a routine health checkup or when you’re being tested for other diseases or conditions, such as HIV infection.

Lymphopenia can cause one of the signs or symptoms below.

  • Frequent infections, such as colds or pneumonia
  • Unusual infections caused by microbes , fungi, or parasites that rarely cause problems for people who have healthy immune system
  • Long-lasting infections, such as tuberculosis
  • Missing or abnormal tonsils (small organs in the back of the throat)
  • Swollen lymph nodes
  • Skin conditions and abnormalities, such as alopecia (sudden hair loss), eczema (long-term itchy, red skin), pyoderma (bumps on skin that turn into swollen, open sores), pale skin, jaundice (yellowing of the skin and eyes), small bruises, and sores in the mouth
  • Failure to thrive
  • A spleen that is larger than normal that your healthcare provider can feel in an exam

Your provider will do a physical exam and ask you about your symptoms to help diagnose lymphopenia. You will also likely need a blood test to confirm the diagnosis.

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