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Participate in NHLBI Clinical Trials

NHLBI sponsors or supports many trials that may be relevant to sickle cell disease. See if you or someone you know is eligible to participate in our clinical trials.

Are you 15 or older with sickle cell disease and willing to be on hydroxyurea? 

This small pilot study is exploring how to optimize hydroxyurea dosing to maximize benefits for more patients with sickle cell disease. Participants must be 15 years or older with the hemoglobin SS type of sickle cell disease. Visit Assessment of Computerized Algorithm-Based Hydroxyurea Dosing on Fetal Hemoglobin Response, Acute Complications, and Organ Function in People with Sickle Cell Disease for more information and to learn how to participate in this study.

Are you 16 or older with sickle cell disease and have a stem cell donor? 

This study is exploring how to improve bone marrow transplant procedures so the body better accepts donor stem cells. Participants must be 16 years or older with sickle cell disease and have a stem cell donor. Visit Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People with Higher Risk of Transplant Failure for more information and to learn how to participate in this study.

Are you an adult with severe sickle cell disease and a well-matched sibling stem cell donor?

This study is exploring a new bone marrow transplant procedure that does not require chemotherapy or destruction of all bone marrow to prevent rejection. Participants must be 18 to 65 with severe sickle cell disease and have a sibling who is a well-matched stem cell donor. Visit Nonmyeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Severe Congenital Anemias Including Sickle Cell Disease (SCD) and Beta-Thalassemia for more information and to learn how to participate in this study.

Are you an adult with sickle cell disease and worried about pulmonary hypertension?

This study is exploring how common pulmonary hypertension is in sickle cell disease patients and how genes affect whether this complication will occur or respond to treatment. Participants must be 18 years or older with sickle cell disease. Visit Determining the Prevalence and Prognosis of Secondary Pulmonary Hypertension in Adult Patients with Sickle Cell Anemia for more information and to learn how to participate in this study.

Are you an adult with sickle cell disease and interested in a new therapy for chronic pain?

This study is assessing whether a new therapy can help manage chronic pain due to sickle cell disease. Participants must be 18 years or older with sickle cell disease. Visit Vaporized Cannabis for Chronic Pain Associated with Sickle Cell Disease for more information and to learn how to participate in this study.

Are you an adult with sickle cell disease who may visit the emergency department for pain? 

This small pilot study is comparing four pain treatments to improve pain-management protocols that emergency departments use to treat adults experiencing vaso-occlusive crises due to sickle cell disease. Participants must be 21 years or older with sickle cell disease. Visit Comparing Acute Pain Management Protocols for Patients with Sickle Cell Disease for more information and to learn how to participate in this study.

Are you an adult with sickle cell disease without a well-matched stem cell donor? 

This study is exploring how to improve bone marrow transplant procedures for adults with sickle cell disease who do not have a full-match stem cell donor. If successful, the study could help make transplant procedures possible for a larger number of patients with sickle cell disease. Participants must be 18 years or older with sickle cell disease and have a family member aged two to 80 who is the correct type of stem cell donor. Visit Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Severe Congenital Anemias Including Sickle Cell Disease and Beta-Thalassemia for more information and to learn how to participate in this study.

Are you pregnant and willing to donate umbilical cord blood to support future sickle cell disease therapies?

This study seeks to determine the best way to collect, store, and handle blood from newborns to help researchers improve future sickle cell disease therapies. Participants must be pregnant women who are 45 years or younger who would like to donate umbilical cord blood from their newborn. Newborns may be healthy or at risk for sickle cell disease or sickle cell trait. Visit Collection and Storage of Umbilical Cord Hematopoietic Stem Cells for Sickle Cell Disease Therapy for more information and to learn how to participate in this study.

Do you or your child have sickle cell disease or a red blood cell disorder? 

This study is interested in understanding pain crises and lung complications that occur in sickle cell disease patients and those with other red blood cell disorders. Participants must be five years or older with known or suspected sickle cell disease, sickle cell trait, or other red blood cell disorders. Participants will have a physical exam and receive standard medical care for sickle cell disease including routine follow-up tests and procedures. Visit Studies of the Natural History of Sickle Cell Disease for more information and to learn how to participate in this study.

Want to know if you can participate in studies on blood disorders? 

This study is collecting medical information from health exams and routine tests and procedures to see if participants may be able to enroll in other studies on blood disorders. Participants must be eight years or older with or without sickle cell disease. Visit Screening of Subjects to Determine Eligibility to Safely Participate in Blood Disorders Studies for more information and to learn how to participate in this study.

 

Sickle Cell Disease Clinical Trials

Learn more about how to participate in a clinical trial.

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Updated: August 2, 2016