Coronary Heart Disease
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Coronary Heart Disease

Coronary Heart Disease Causes and Prevention

Coronary heart disease may have more than one cause, including plaque buildup or problems that affect how the heart's blood vessels work. Taking steps to keep your heart and blood vessels healthy early in life can prevent risk factors from developing.

What causes coronary heart disease?

Plaque buildup in the large arteries on the heart’s surface is the leading cause of coronary heart disease. Some people may have coronary heart disease if the blood vessels in their heart do not respond correctly when the heart needs more oxygen-rich blood. 

Plaque buildup 

Plaque buildup in the arteries is called atherosclerosis. The buildup causes the arteries to harden and become narrower over time. This can lower or block blood flow to the heart muscle.

Normal vs a blocked artery
Normal versus blocked artery. The image on the left shows the location of the coronary arteries in the heart. The top right image shows a healthy coronary artery with typical blood flow. The bottom right image shows a blocked coronary artery, narrowed by plaque buildup on the walls of the vessel. Medical Illustration Copyright © 2024 Nucleus Medical Media, All Rights Reserved.

 

Small amounts of plaque can also build up inside the small blood vessels in the heart, causing coronary microvascular disease.

Problems with how the blood vessels work

Sometimes, the heart’s blood vessels do not respond to signals that the heart needs more oxygen-rich blood. Coronary arteries typically widen to allow more blood flow to the heart when a person is physically active or under stress. In coronary heart disease, the size of these arteries may not change, or they may even narrow.

The cause of these problems is unclear, but it may involve damage or injury to the walls of the arteries or tiny blood vessels from long-term inflammation , high blood pressure, or diabetes.

Damage to the inner walls of the larger coronary arteries can cause them to spasm (suddenly tighten), which is called a vasospasm. The spasm causes the arteries to narrow temporarily, which blocks blood flow to the heart.

Coronary microvascular disease in small arteries and obstructive coronary artery disease in large arteries
Coronary microvascular disease in small arteries and obstructive coronary artery disease in large arteries. Figure A shows the small coronary artery network, which includes a healthy artery and an artery with coronary microvascular disease. Figure B shows a large coronary artery with plaque buildup.

 

How can you assess your progress toward a heart-healthy lifestyle?

Watch this video to see tips about actions you can take to help protect your heart.

The American Heart Association's Life's Essential 8TM are key measures for improving and maintaining the health of your heart and blood vessels. Your healthcare provider can set up a plan that works for you based on your lifestyle, your home and neighborhood environments, and your culture. This may mean taking steps to improve your diet, be physically active, manage other medical conditions, and help you quit smoking.

How can you prevent coronary heart disease?

Coronary heart disease is largely preventable. Studies show that heart-healthy living — quitting smoking or never starting, eating healthy foods, and being physically active — throughout life can prevent or delay coronary heart disease and its complications in most people. A heart-healthy lifestyle is important for people of all ages, but it is especially important for anyone who has other risk factors for coronary heart disease. 

Why is it important to start prevention early?

Risk factors for coronary heart disease begin in childhood. Therefore, it’s important to develop healthy living habits in childhood, including good nutrition and physical activity, to prevent risk factors from developing. 

Because overweight and obesity are becoming more common at young ages, children between ages 9 to 11 should be screened for unhealthy cholesterol levels. Your child’s healthcare provider may suggest screening your child at a younger age if a parent or grandparent had coronary heart disease, a heart attack or stroke, at age 55 or earlier if male, or at age 65 or earlier if female.

Some children can develop atherosclerosis or even have a heart attack or stroke if they have a genetic condition called familial hypercholesterolemia.

Treatments for children who have plaque buildup in their coronary arteries may include heart-healthy lifestyle changes and medicines such as statins. If your child has severe obesity, their healthcare provider may discuss options such as weight-loss surgery and — maybe in the future — GLP-1 RA (glucagon-like peptide-1 receptor agonists) medicines. GLP-1 RA medicines are for treating diabetes, but some providers also prescribe them for weight loss.

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