Sickle Cell Disease

for Health Professionals
Clinical Practice Guidelines

The IOM (2011) defined clinical practice guidelines as "statements that include recommendations intended to optimize patient care that are informed by a systematic review of evidence and an assessment of the benefits and harms of alternative care options."

Nkechinyem (Nke) Nwabuzor
Research Feature
They ranged in age from 15 to 61—four African American women, all with stories to tell about their struggles with sickle cell disease, all with stories about a common experience that helped them through those struggles: participating in clinical trials. It mattered, said the women, all of whom had joined trials funded by the National Institutes of Health (NIH). Their participation helped them better manage their condition, they said. It allowed promising treatments to be tested, and at least in one case, it led to a virtual cure. The trial participants spoke to a standing-room-only session at...